中国药房2012，Vol.23Issue(28)：2654-2655,2.DOI:10.6039/j.issn.1001-0408.2012.28.24
硝苯地平控释片联合坎地沙坦酯治疗原发性高血压合并腹型肥胖的临床观察
Clinical Observation of Nifedipine Controlled-release Tablets Combined with Candesartan Cilexetil Tablets for Primary Hypertension Complicating with Abdominal Obesity
摘要
Abstract
OBJECTIVE: To observe the effect of Nifedipine controlled-release tablets combined with Candesartan cilexetil tablets for primary hypertension complicating with abdominal obesity. METHODS: 90 primary hypertension patients with abdominal obesity were randomly divided into combined therapy group, nifedipine group and candesartan cilexetil group. They were given Nifedipine controlled-release tablets+Candesartan cilexetil tablets, Nifedipine controlled-release tablets, Candesartan cilexetil tablets for 6 months respectively. The changes of 24 h ambulatory blood pressure, interventricular septal thickness and hs-CRP were observed before and after treatment. RESULTS: The blood pressure of patients in all 3 groups were all decreased, especially in combined therapy group (P<0.05). After treatment, the interventricular septal thickness and hs-CRP of combined therapy group were decreased more significantly than other 2 groups (P<0.05). No serious ADR was found in 3 groups. CONCLUSION: For primary hypertension complicating with abdominal obesity, Nifedipine controlled-release tablets combined with Candesartan cilexetil tablets can effectively control the blood pressure, decrease the concentration of hs-CRP in serum and reverse myocardial hypertrophy with good safety.
关键词
硝本地平控释片/坎地沙坦/原发性高血压/肥胖Key words
Nifedipine controlled-release tablets/ Candesartan cilexetil tablets/ Primary hypertension/ Obesity分类
医药卫生引用本文复制引用
龚恒美,胡中伟,龚恒丽..硝苯地平控释片联合坎地沙坦酯治疗原发性高血压合并腹型肥胖的临床观察[J].中国药房,2012,23(28):2654-2655,2.
