中国药房2012，Vol.23Issue(28)：2670-2672,3.DOI:10.6039/j.issn.1001-0408.2012.28.31
吡嗪酰胺致严重高尿酸血症78例临床分析
Clinical Analysis of 78 Cases of Pyrazine Amide-induced Serious Hyperuricemia
摘要
Abstract
OBJECTIVE: To investigate the influential factors of pyrazine amide-induced serious hyperuricemia and the effect of it on anti-tuberculosis treatment. METHODS: 78 patients with pyrazine amide-induced serious hyperuricemia in our hospital were analyzed from gender, age, body weight, complications, drug dosage, the time of serious hyperuricemia appearing. RESULTS: Pyrazine amide-induced serious hyperuricemia was related with following factors: men, older than 60 years old, body mass index ≥28, hypertensive patients with diabetes suffered from hyperuricemia easily, compared with control group (P<0.05); the incidence of hyperuricemia increased after 2 weeks of treatment (80%). Although the incidence of hyperuricemia was in high level, but little case need to stop taking drug in the clinical treatment. CONCLUSION: Obese older male hypertensive patients with diabetes mellitus shows high incidence of serious hyperuricemia. Great importance should be attached to the occurrence of serious hyperuricemia within 2 weeks.
关键词
吡嗪酰胺/高尿酸血症/肥胖Key words
Pyrazine amide/ Hyperuricemia/ Obese分类
医药卫生引用本文复制引用
吴同柱..吡嗪酰胺致严重高尿酸血症78例临床分析[J].中国药房,2012,23(28):2670-2672,3.
