中国药房2012，Vol.23Issue(29)：2740-2743,4.DOI:10.6039/j.issn.1001-0408.2012.29.19
尼莫地平双层渗透泵片的制备及其体外释放度考察
Preparation and in Vitro Release of Nimodipine Two-layer Osmotic Pump Tablets
张冠男 1白靖 2曹德英1
作者信息
- 1. 河北医科大学药学院,石家庄050017
- 2. 河北医科大学第四医院,石家庄050017
- 折叠
摘要
Abstract
OBJECTIVE: To prepare Nimodipine two-layer osomatic pump tablets and to study the in vitro release of it. METHODS: The preparation formula of Nimodipine two-layer osomatic pump tablets was optimized by orthogonal design with accumulative release rate as index using the amount of PEO 200000 and osmotic promoter NaCl, the content of PEG 2000 and the weight growth of coating membrane as factors. The in vitro release of preparation was determined in accordance with the method stated in Chinese Pharmacopeia. RESULTS: The optimal formula was as follows: PEO 200000 in drug-containing layer of 80 mg, NaCl of 10 mg, PEO 5000000 in push layer of 40 mg, PEG 2000 of 8%, weight gain for coating membrane of 8%. The release rate was constant, the accumulative release rate was above 90% in 12 h. CONCLUSION: The preparation of Nimodipine two-layer osomatic pump tablets is stable, and the in vitro drug release shows excellent zero-release profile within 12 h (r=0.990 3), and in line with controlled requirements.
关键词
尼莫地平/双层渗透泵/制备/正交设计/体外释放度Key words
Nimodipine/ Two-layer osmotic pump/ Preparation/ Orthogonal design/ In vitro drug release分类
医药卫生引用本文复制引用
张冠男,白靖,曹德英..尼莫地平双层渗透泵片的制备及其体外释放度考察[J].中国药房,2012,23(29):2740-2743,4.
