中国药房2012，Vol.23Issue(30)：2790-2792,3.DOI:10.6039/j.issn.1001-0408.2012.30.03
1例脓毒症合并急性肾衰竭患者使用万古霉素的药学监护
Pharmaceutical Care for a Patient with Sepsis Complicating with Acute Renal Failure Treated by Vancomycin
沈艳琳 1卜书红1
作者信息
- 1. 上海交通大学医学院附属新华医院药剂科,上海200092
- 折叠
摘要
Abstract
OBJECTIVE: To explore the method that clinical pharmacists carry out the pharmaceutical care for patient with severe infection in ICU. METHODS: Based on knowledge of pharmacy and determining plasma concentrations of vancomycin, clinical pharmacist adjusted the vancomycin dosage regimens for a patient with sepsis complicating with acute renal failure. RESULTS: It was safe and efficient to treat the patients suffering from sepsis and renal failure with vancomycin by monitoring the plasma concentration and controlling it in the appropriate range. In order to compensate the loss of vancomycin removed by continuous ve-no-venous hemodiafiltration (CVVHDF) treatment, the dose must be increased. For severely infected patients, anti-infective efficacy of vancomycin ranged 15~20 μg·mL-1 was better than under 10 μg·mL-1. Clinical pharmacists ensured the clinical safety and efficacy through the pharmaceutical care, and the patient experienced the treatment process smoothly and was improved greatly to leave hospital. CONCLUSIONS: Clinical pharmacists help doctors formulate individual dosage regimens for severe patients, while contradictions among disease, drug and mechanical treatment should be taken into consideration.
关键词
临床药师/脓毒症/肾衰竭/万古霉素/治疗药物监测Key words
Clinical pharmacist/Sepsis/Renal failure/Vancomycin/Therapeutic drug monitoring分类
医药卫生引用本文复制引用
沈艳琳,卜书红..1例脓毒症合并急性肾衰竭患者使用万古霉素的药学监护[J].中国药房,2012,23(30):2790-2792,3.
