中国药房2012，Vol.23Issue(30)：2829-2830,2.DOI:10.6039/j.issn.1001-0408.2012.30.18
我院2011年碳青霉烯类抗生素用药频度与鲍曼不动杆菌对其耐药率的相关性研究
Study on the Correlation of DDDs of Carbapenem Antibiotics with the Resistance of Acinetobacter Baumannii to in Our Hospital in 2011
黄晓波 1张敏 1龙恩武 1喻华1
作者信息
- 1. 四川省医学科学院/四川省人民医院,成都610072
- 折叠
摘要
Abstract
OBJECTIVE: To analyze the correlation of DDDs of carbapenem antibiotics with the resistance of Acinetobacter baumannii to it, and to provide evidence for rational drug use in the clinic. METHODS: K-B disk diffusion method was applied for determining susceptibility to antimicrobial agents, and SPSS 16.0 software was used for data analysis; the DDDs of antibiotics was analyzed by the defined daily dose (DDD) method recommended by the WHO. RESULTS: In 2011, the DDDs of carbapenem antibiotics were declined by quarter. The quantity in the fourth quarter was decreased by 9.74% , compared to the first quarter. The DDDs of imipenem and panipenem were decreased by 73.91% and 95.22% respectively, while meropenem showed no significant difference, and the resistant rate of A. baumannii to carbapenem was decreased by 33.6% , compared with the same period. CONCLUSION: The resistant rate of A. baumannii presents a positive correlation to DDDs of carbapenem (r=0.996,P<0.05), positively correlated with DDDs of imipenem, panipenem (r=0.947,0.895,P<0.05), showing no significant positively correlated with DDDs of meropenem (r=- 0.485,P>0.05).
关键词
碳青霉烯类抗生素/用药频度/鲍曼不动杆菌/相关性Key words
Carbapenem antibiotics/ DDDs/ Acinetobacter baumannii/ Correlation分类
医药卫生引用本文复制引用
黄晓波,张敏,龙恩武,喻华..我院2011年碳青霉烯类抗生素用药频度与鲍曼不动杆菌对其耐药率的相关性研究[J].中国药房,2012,23(30):2829-2830,2.
