中国医科大学学报2012，Vol.41Issue(4)：303-306,4.
普伐他汀对2型糖尿病大鼠视网膜组织中转化生长因子β1表达的影响
Effects of Pravastatin on the Expression of TGF-β1 in Retina of Type Ⅱ Diabetes Rats
摘要
Abstract
Objective To investigate the effects of pravastaun on the expression of TGF-β1 in the retina of type II diabetes rats,and the preventive effect of piavastatin in the pathological changes in diabetic retina. Methods Fifty-four Wistar rals were randomly divided into three groups:normal group,diabetic group and pravastatin treatment group,with 18 rats each. Rats in diabetic group and pravastatin treatment group were induced with streptozotocin to type II diabetes rat model. The rats in the first two groups were fed with normal diet and the rats in the pravastatin treatment group were fed with normal diet plus pravastatin 100 mg·kg-1·d-1. After 30 weeks,rals in all groups were sacrificed. The expression of TGF-β1 in retinal tissue was detected with immunohistochemistry and Real-time PCR. Results Positive expression of TGF-β1 was in cytoplasm of retina ganglion cells. Compared with the normal group, the thickness of retina became thinning and the number of ganglion cells decreased in the diabetic group,while those were not significantly changed in the pravastatin treatment group. The expression level of TGF-β1 in diabetic group was significantly higher than that in the normal group (P < 0.05) .and the expression level of TGF-β1 in pravastatin treatment group was significantly lower than that in diabetic group (P < 0.05). Conclusion Pravastatin could control and delay the morphological changes of diabetic retinopathy.and pravastatin could decrease the expression of TGF-β1 in diabetic retina.关键词
普伐他汀/转化生长因子β1/糖尿病视网膜病变Key words
pravastatin/ TGF-β1/ diabetic retinopathy分类
医药卫生引用本文复制引用
李婕,杨宁,王思敏,林婷婷,宁宏..普伐他汀对2型糖尿病大鼠视网膜组织中转化生长因子β1表达的影响[J].中国医科大学学报,2012,41(4):303-306,4.基金项目
沈阳市科技局资助项目(沈科发2008081647) （沈科发2008081647）
