中国医科大学学报2012，Vol.41Issue(4)：343-346,4.
3.0T MR弥散加权成像及张量成像评价肝纤维化的临床研究
MR Diffusion Weighted Imaging and Diffusion Tensor Imaging for Quantification of Liver Fibrosis at 3.0T
摘要
Abstract
Objective To evaluate MR diflusion weighted imaging(DWI)and diflusion tensor imaging (DTI) for quantifying liver fibrosis in patients with chronic viral hepatitis. Methods A total of 8 healthy volunteers and 40 patients with chronic HBV or HCV hepatitis who underwent liverbiopsy,and were enrolled in this study using a 3.0T MR unit at b values of 0,800 s/mm2. The apparent diffusion coefficient (ADC) and mean diffusion (MD) were measured in the liver parenchyma respectively and compared between patients stratified by fibrosis stage. Results The mean ADC values were significantly lower than the MD values in volunteers and patients (1.26±0.12×10-3 mm2/s, 1.39±0.14×10-3 mm2/s;Z =-5.775,P< 0.01). ADC was negatively correlated with the staging of liver fibrosis,which was more accurate in staging than MD (r =-0.686,P< 0.01 ;r =-0.481,P< 0.01). There was no significant difference in liver MD among individual stages of fibrosis (except for S4 vs. S0,S1 ,P =0.002,0.026). There were significant differences in liver ADC between control livers and moderate to severe fibrosis (S0 vs. S2,S3,S4,P< 0.05),and between cirrhosis and mild to moderate fibrosis (S4 vs. S1,S2,S3,P =0.003,0.041,0.014). ROC analysis showed that ADC was superior to MD for the detection of fibrosis stage ≥2,stage ≥3 and stage ≥4 (area under the ROC curve,ADC:0.879,0.823,0.866;MD:0.796,0.743,0.725). Conclusion DWI can be used to predict the liver fibrosis of chronic viral hepatitis with acceptable sensitivity and specificity,and perform better than DTI at a 3.0T MR unit.关键词
肝纤维化/弥散加权成像/弥散张量成像/病毒性肝炎Key words
liver fibrosis/ difiusion weighted imaging/ difiusion tensor imaging/ viral hepatitis分类
医药卫生引用本文复制引用
石喻,郭启勇,张兰,卞胜晰..3.0T MR弥散加权成像及张量成像评价肝纤维化的临床研究[J].中国医科大学学报,2012,41(4):343-346,4.基金项目
国家自然科学基金资助项目(81071123) （81071123）
