中国医科大学学报2012，Vol.41Issue(6)：550-553,558,5.
具有基底细胞样免疫表型的三阴性乳腺癌临床病理分析
Clinicopathological Analysis of Triple-negative Breast Cancer with Basal Cell-like Phenotype
摘要
Abstract
Objective To detect the expression of triple-negative breast cancels (TNBCs) with the basal cell-like phenotype, to explore whether TNBCs have the basal cell-like phenotype, and to study the clinicopathological features and Ki67,p53 expressions differences between basal cell-like and non-basal cell-like TNBCs. Methods Immunohistochemical staining was used to detect the protein expressions of CK5/6,CK14,EGFR,Ki67 and P53 in 42 cases of triple-negative breast invasive carcinoma. We studied the relationship among the expression of basal cell-like phenotvpe.clinieopathological features and the expressions of Ki67 and P53. Results Twenty four cases expressed one or several basal cell-like phenotype markers (CK5/6,CK14,EGFR),accounting for 57.1% of the 42 triple negative breast patients,while CK14 was not solely expressed. Eighteen cases (42.9%) did not express CK5/6.CK14 or EGFR. Twenty four TNBCs with basal cell-like phenotype had similar morphological characteristic and nuclear levels,including grade III (22 cases) and grade II (2 cases). And Ki67 was expressed in 22 out of 24 cases. The breast cancer cells nuclear levels of 18 non-basal cell-like cases snowed grade III (3 cases) and grade I (15 cases).grade II (15 cases),and Ki67 was expressed in 8 out of 18 cases. The difference in nuclear level and Ki67 expression between basal-like and non-basal-like TNBCs was statistically significant (P < 0.01). Conclusion Basal cell-like phenotype of TNBCs is a breast cancer with a unique phenotype and morphological characteristics. Characteristic morphological changes and clinical use of CK5/6, EGFR and Ki67 marked by immunohistochemical staining had practical significance in the diagnosis and prognosis of such lesions.关键词
三阴性乳腺癌/基底细胞样免疫表型/临床病理/预后指标Key words
triple negative breast cancers/ basal cell-like phenotype/ clinicopathological / prognostic indicators分类
医药卫生引用本文复制引用
张升瑞,王星,孙洁,宦大为,王翠芳..具有基底细胞样免疫表型的三阴性乳腺癌临床病理分析[J].中国医科大学学报,2012,41(6):550-553,558,5.基金项目
沈阳医学院科研基金资助项目(20111030) （20111030）
