中国医学科学院学报2012，Vol.34Issue(4)：369-374,6.DOI:10.3881/j.issn.1000-503X.2012.04.011
超敏妊娠相关血浆蛋白-A对急性冠状动脉综合征患者预后的预测价值
Prognostic Value of Ultra-sensitive Pregnancy Associated Plasma Protein-A in Patients with Acute Coronary Syndorme
摘要
Abstract
Objective To investigate the prognostic value of ultra-sensitive pregnancy associated plasma protein-A ( PAPP-A ) level in the early phase of acute coronary syndrome ( ACS) attack. Methods Patients diagnosed as ACS were enrolled and the level of circulatory PAPP-A was measured within 12 hours after ACS attack. The patients were followed at the time of 1st, 6th, and 12th months post-ACS attack in order to observe the incidence of the cardiovascular adverse events. According to the highest quintile, the patients were devided into 2 groups: high level (≥26. 08 μg/L) group and low level ( <26. 08 μg/L) group, to evaluate the association between the level of PAPP-A and the incidence of the cardiovascular events. Results Compared with the low level group, the incidence of the composite outcome is significantly increased in the high level group, and the values of OR are 4. 76 , 4. 38, 3. 75 for 1 st, 6th, 12th months respectively ( P = 0. 000). For myocardial infarction (MI) + cardiac death ( CD) the values of OR were 9. 81 , 6. 08 , 4. 12 ( P < 0. 01 ). Multivariate logistic regression analysis demonstrates that PAPP-A was an independent risk factor for the cardiovascular adverse events in the early, median, and late phase of ACS (P<0. 05). Conclusion In the early phase of ACS attack, the elevation of PAPP-A is an independent risk factor for the occurrence of cardiovascular adverse events.关键词
急性冠状动脉综合征/妊娠相关血浆蛋白-A/危险因素/预后Key words
acute coronary syndrome/pregnancy associated plamsa protien-A/risk factors/prognosis分类
医药卫生引用本文复制引用
孙玉发,袁凤仪,曹剑,衣志勇,蒋知新,范利,李小鹰,李美芹,张波,查政,刘亚巍..超敏妊娠相关血浆蛋白-A对急性冠状动脉综合征患者预后的预测价值[J].中国医学科学院学报,2012,34(4):369-374,6.基金项目
国家科技支撑计划(2009BA186B04) （2009BA186B04）
