中国医学科学院学报2012，Vol.34Issue(4)：379-383,5.DOI:10.3881/j.issn.1000-503X.2012.04.013
过氧化物酶体增殖激活受体γ激动剂对高血压患者外周血单核来源巨噬细胞血管紧张素转化酶2 mRNA表达的影响
Effect of Peroxisome Proliferator Activated Receptor γ Agonist on Angiotensin Converting Enzyme 2 mRNA Expression in Monocyte-derived Macrophages of Essential Hypertensive Patients
摘要
Abstract
Objective To study the effect of peroxisome proliferator activated receptor y ( PPAR-y) agonist on the angiotensin converting enzyme 2 (ACE2 ) mRNA expression in monocyte-derived macrophages of essential hypertensive patients. Methods Totally 57 essential hypertensive patients were randomly divided into three groups: conventional treatment group ( n = 18 ) , telmisartan group ( n = 19 ) , and benazepril group ( n =20 ); 20 patients with normal blood pressure were also selected as the control group. Monocyte-derived macro-phages were isolated from blood samples of patients in all four groups. The expression of ACE2 mRNA in monocyte-derived macrophages was detected by RT-PCR before treatment and 4 and 12 weeks after treatment. Results Four and 12 weeks after treatment, the systolic pressure and diastolic pressure of telmisartan group and benaze-pri group were significantly lower than that of the conventional treatment group ( all P <0. 01 ) , and the systolic pressure and diastolic pressure of telmisartan group were significantly lower than that of the benazepri group (both P <0. 01 ). The expression of ACE2 mRNA in monocyte-derived macrophages were significantly lower in essential hypertensive patients than that in control group (P < 0. 01 ). After having been treated for 4 weeks and 12 weeks, the expression of ACE2 mRNA in monocyte-derived macrophages of hypertensive patients in telmisartan and benazepril groups were significantly higher than that in conventional treatment group ( all P < 0. 01 ) , and the expression of ACE2 mRNA in telmisartan group was significantly higher than that in benazepril group ( both P < 0. 01 ) . Conclusion PPAR-y agonist could increase the ACE2 mRNA expression in monocyte-derived macrophages of essential hypertensive patients.关键词
过氧化物酶体增殖激活受体γ激动剂/血管紧张素转化酶2/原发性高血压Key words
peroxisome proliferated activated receptor 7 agonist/angiotensin converting enzyme 2 mRNA/essential hypertension分类
医药卫生引用本文复制引用
李永勤,王世捷,王聪霞,高登峰,丁抗宁,牛小麟..过氧化物酶体增殖激活受体γ激动剂对高血压患者外周血单核来源巨噬细胞血管紧张素转化酶2 mRNA表达的影响[J].中国医学科学院学报,2012,34(4):379-383,5.基金项目
陕西省科技攻关项目[2007K13-03(13)] （13）
