中国药业2012，Vol.21Issue(13)：14-15,2.
吸入糖皮质激素对慢性阻塞性肺病急性加重期患者诱导痰中炎性标志物及肺功能的影响
Corticosteroid Inhalation on Expression of Inflammatory Molecules Ininduced Sputum and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Diseases at Acute Exacerbation Phase
朱丹 1赵建平 1陈 慧 1朱景倩 1涂军伟 1骆健锋 1盛 琳1
作者信息
- 1. 浙江省金华市中心医院呼吸内科,浙江金华321000
- 折叠
摘要
Abstract
Objective To investigate the potential roles of soluble inter - cellular adhesion molecule-1 (SICAM-1) and interleukin - 8 (IL-8) in pathogenesis of chronic obstructive pulmonary diseases (COPD),and to evaluate the effects of corticosteroid inhalation on development of COPD. Methods Seventy patients with COPD at acute exacerbation phase were randomized into routine treatment group (n = 35) and routine treatment plus corticosteroid group (n = 35).In parallel,a healthy control group was set up (n =20). Patients in different groups were tested for their pulmonary function one day and two weeks after admission,respectively. Pulmonary function was evaluated as percent of forced expiratory volume in 1 second (FEV1.0)/ predicted FEV1.0 (FEV1.0pre). SICAM - 1 and IL-8 in induced sputum were assayed with ELISA kit. Results The levels of SICAM -1 and IL-8 in induced sputum pre - and post - treatment from patients in two groups were higher than that in healthy control (P<0.01),while FEV1.0pre values were lower than that in healthy control (P < 0.01). Compared to that of pretreatment, post - treatment levels of SICAM - 1 and IL-8 in induced sputum from patients in two groups were lowered (P<0.01) and FEV1.0yax. Significantly improved (P<0.01) at remission.There was not any significant difference on pre-treat-ment FEV1.0pre,SICAM -1 and IL-8 in induced sputum between routine treatment group and routine treatment plus corticosteroid group at acute exacerbation phase (P>0. 05). However, the post - treatment FEV1.0pac was much higher (P<0.01),and IL-8 (P<0.05) was lower in routine treatment plus corticosteroid group than that in routine treatment group. Surprisingly,there was not any significantly difference on post - treatment levels of SICAM-1 between the two treatment groups (P>0.05). Conclusion It's suggested that both SICAM-1 and IL-8 may be involved in the inflammatory process of COPD. It' a demonstrated that short - term corticosteroid inhalation could inhibit expression of IL-8 but not SICAM - 1,and significantly improve the obstruction status of airflow in patients with COPD at acute exacerbation phase.关键词
慢性阻塞性肺病/诱导痰/白细胞介素8/可溶性细胞间黏附分子-1/肺功能Key words
chronic obstructive pulmonary diseases/induced sputum/IL — 8/SICAM - 1/pulmonary function分类
医药卫生引用本文复制引用
朱丹,赵建平,陈 慧,朱景倩,涂军伟,骆健锋,盛 琳..吸入糖皮质激素对慢性阻塞性肺病急性加重期患者诱导痰中炎性标志物及肺功能的影响[J].中国药业,2012,21(13):14-15,2.
