中国药业2012，Vol.21Issue(13)：39-41,3.
金蒿抗流感滴丸制备工艺及其含量测定
Preparation and Determination of Jinhao Drop Pills
摘要
Abstract
Objective To study the preparation of Jinhao Drop Pills and establish the content determination method. Methods Single experiment and orthogonal design were used to optimize the temperature of drug,drop distance and drop rate. The hardness,weight variation, resolving time and grain roundness were used as criteria for evaluation. The orthogonal experiment was used to determine the optimum preparation according to the hardness of drop pills,appearance and weight variation. HPLC was used to determinate the concentri-tion of rupestric acid. Results The optimum preparation condition was PEG4000 - drug 2 : 1, the temperature of drug was 85 ℃ , drop rate was 40 drops/min, the drop distance was 8 cm. The linear relationship of rupestric acid was found in the range of 9.72-77.76 μg/mL(r = 0. 999 3) and the average recovery was 99. 10% (RSD = 0. 56% ). Conclusion This process is feasible. The methord is accurate and simple.关键词
金蒿滴丸/制备工艺/聚乙二醇/正交试验/一枝蒿酮酸Key words
Jinhao Drop Pills/ preparation/ PEC/ orthogonal experiment/ rupestric acid分类
化学化工引用本文复制引用
薛桂蓬,顾政一,张 洁,邢建国,王云飞,于 宁..金蒿抗流感滴丸制备工艺及其含量测定[J].中国药业,2012,21(13):39-41,3.基金项目
新疆维吾尔自治区科技支疆项目,项目编号:200991134. （）
