中华医学杂志（英文版）2012，Vol.125Issue(13)：2250-2254,5.DOI:10.3760/cma.j.issn.0366-6999.2012.13.002
Effect of high-dose rosuvastatin loading before percutaneous coronary intervention in female patients with non-ST-segment elevation acute coronary syndrome
Effect of high-dose rosuvastatin loading before percutaneous coronary intervention in female patients with non-ST-segment elevation acute coronary syndrome
GAO Yuan 1JIA Zhi-mei 1SUN Yu-jiao 1ZHANG Zhi-hong 1REN Li-na 1QI Guo-xian1
作者信息
- 1. Department of Cardiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China
- 折叠
摘要
Abstract
Background Early loading statin therapy before percutaneous coronary intervention (PCI) is associated with reduced mortality and periprocedural myocardial injury.The aim of this study was to study the effect of rosuvastatin loading therapy before PCI in female patients with non-ST-segment elevation acute coronary syndrome (NSTEACS).Methods Consecutive 117 female patients with NSTEACS were randomly assigned to either the group of rosuvastatin loading before PCI (20 mg 12 hours before angioplasty procedure,with a further 10 mg dose 2 hours before procedure,the loading dose group,n=59) or the no rosuvastatin treatment group before PCI (control group,n=58).Periprocedural myocardial injury,periprocedural changes of high sensitivity C-reactive protein (hs-CRP),interleukin (IL)-1,IL-6,and tumor necrosis factor (TNF)-α in serum and the incidence of major adverse cardiac events (MACE) 3 months and 6 months later were assessed.Results The incidence of periprocedural myocardial injury was higher in control group than loading dose group (CKMB:10.17％ vs.25.86％,P=0.027; Troponin Ⅰ:11.86％ vs.29.31％,P=0.019).MACE occurred in 1.69％ of patients in loading dose group and 12.07％ of those in control group 3 months after procedure (P=0.026),3.39％ vs.17.24％ at 6 months (P=0.014).The levels of hs-CRP,IL-1,IL-6,and TNF-α in serum were not significantly different between the two groups before PCI,but after PCI they were significantly higher in control group.Conclusions High-dose rosuvastatin loading before PCI significantly reduced periprocedural myocardial injury and periprocedural inflammation cytokines release and improved 3-month and 6-month clinical outcomes in female patients with NSTEACS who underwent PCI.关键词
rosuvastatin/acute coronary syndrome/angioplasty/female/inflammationKey words
rosuvastatin/acute coronary syndrome/angioplasty/female/inflammation引用本文复制引用
GAO Yuan,JIA Zhi-mei,SUN Yu-jiao,ZHANG Zhi-hong,REN Li-na,QI Guo-xian..Effect of high-dose rosuvastatin loading before percutaneous coronary intervention in female patients with non-ST-segment elevation acute coronary syndrome[J].中华医学杂志（英文版）,2012,125(13):2250-2254,5.
