|国家科技期刊平台
| 注册
首页|期刊导航|中华医学杂志（英文版）|Mortality and morbidity of acute hypoxemic respiratory failure and acute respiratory distress syndrome in infants and young children

Mortality and morbidity of acute hypoxemic respiratory failure and acute respiratory distress syndrome in infants and young children

ZHU Yan-feng YU Wen-liang XIE Min-hui YAN Chao-ying LU Zhu-jin SUN Bo XU Feng LU Xiu-lan WANG Ying CHEN Jian-li CHAO Jian-xin ZHOU Xiao-wen ZHANG Jian-hui HUANG Yan-zhi

中华医学杂志（英文版）2012，Vol.125Issue(13)：2265-2271,7.
✕
中华医学杂志（英文版）2012，Vol.125Issue(13)：2265-2271,7.DOI:10.3760/cma.j.issn.0366-6999.2012.13.005

Mortality and morbidity of acute hypoxemic respiratory failure and acute respiratory distress syndrome in infants and young children

Mortality and morbidity of acute hypoxemic respiratory failure and acute respiratory distress syndrome in infants and young children

ZHU Yan-feng 1YU Wen-liang 2XIE Min-hui 3YAN Chao-ying 4LU Zhu-jin 1SUN Bo 1XU Feng 5LU Xiu-lan 6WANG Ying 7CHEN Jian-li 8CHAO Jian-xin 9ZHOU Xiao-wen 10ZHANG Jian-hui 11HUANG Yan-zhi12

作者信息

  • 1. Departments of Pediatrics and Pediatric Critical Care, Children's Hospital of Fudan University, Shanghai 201102, China
  • 2. Department of Pediatric Critical Care, Nanjing Children's Hospital, Nanjing, Jiangsu 210008, China
  • 3. Department of Pediatric Critical Care, Children's Hospital of Soochow University, Suzhou, Jiangsu 215000, China
  • 4. Departments of Pediatric Critical Care, First Hospital of Jilin University, Changchun, Jilin 130021, China
  • 5. Department of Pediatric Critical Care, Children's Hospital of Chongqing Medical University, Chongqing 400014, China
  • 6. Department of Pediatric Critical Care, Hunan Children's Hospital, Changsha, Hunan 410007, China
  • 7. Department of Pediatric Critical Care, Shanghai Children's Medical Center of Shanghai Jiao Tong University, Shanghai 200127, China
  • 8. Department of Pediatric Critical Care, Guiyang Children's Hospital, Guizhou, Guiyang 550003, China
  • 9. Department of Pediatric Critical Care, Quanzhou Children's Hospital, Quanzhou, Fujian 362000, China
  • 10. Department of Pediatric Critical Care, Jinan Children's Hospital, Jinan, Shandong 250022, China
  • 11. Department of Pediatric Critical Care, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong 510000, China
  • 12. Department of Pediatric Critical Care, Changchun Children's Hospital, Changchun, Jilin 130061, China
  • 折叠

摘要

Abstract

Background Acute hypoxemic respiratory failure (AHRF) often develops acute respiratory distress syndrome (ARDS),and its incidence and mortalities in critically ill pediatric patients in China were 2％ and 40％ respectively.This study aimed at prospectively investigating incidence,causes,mortality and its risk factors,and any relationship to initial tidal volume (VT) levels of mechanical ventilation,in children ≤5 years of age with AHRF and ARDS.Methods In 12 consecutive months in 23 pediatric intensive care units (PICU),AHRF and ARDS were identified in those requiring ＞12 hour intratracheal mechanical ventilation and followed up for 90 days or until death or discharge.ARDS was diagnosed according to the American-European Consensus definitions.The mortality and ventilation free days (VFD) were measured as the primary outcome,and major complications,initial disease severity,and burden were measured as the secondary outcome.Results In 13 491 PICU admissions,there were 439 AHRE,of which 345 (78.6％) developed ARDS,resulting in incidences of 3.3％ and 2.6％,and corresponding mortalities of 30.3％ and 32.8％ respectively along with 8.2 and 6.7 times of relative risk of death in those with pneumonia (62.9％) and sepsis (33.7％) as major underlying diseases respectively.No association was found in VT levels during the first 7 days with mortality,nor for VT at levels ＜6,6-8,8-10,and ＞10 ml/kg in the first 3 days with mortality or length of VFD.By binary Logistic regression analyses,higher pediatric risk of mortality score Ⅲ,higher initial oxygenation index,and age ＜1 year were associated with higher mortality or shorter VFD in AHRF.Conclusions The incidence and mortalities of AHRF and ARDS in children ≤5 years were similar to or lower than the previously reported rates (in age up to 15 years),associated with initial disease severity and other confounders,but causal relationship for the initial VT levels as the independent factor to the major outcome was not found.

关键词

acute respiratory distress syndrome/hypoxemia/respiratory failure/morbidity/mortality/respiratory therapy

Key words

acute respiratory distress syndrome/hypoxemia/respiratory failure/morbidity/mortality/respiratory therapy

引用本文复制引用

ZHU Yan-feng,YU Wen-liang,XIE Min-hui,YAN Chao-ying,LU Zhu-jin,SUN Bo,XU Feng,LU Xiu-lan,WANG Ying,CHEN Jian-li,CHAO Jian-xin,ZHOU Xiao-wen,ZHANG Jian-hui,HUANG Yan-zhi..Mortality and morbidity of acute hypoxemic respiratory failure and acute respiratory distress syndrome in infants and young children[J].中华医学杂志（英文版）,2012,125(13):2265-2271,7.

基金项目

This study was supported by grants from the Program for Outstanding Medical Science Leader by the Shanghai Municipal Department of Health (No.LJ06038),and the Doctorate Research Program by the Ministry of Education (No.20090071110061). （No.LJ06038）

中华医学杂志（英文版）

OACSCDCSTPCD

0366-6999

访问量0
|
下载量0
段落导航相关论文