中华医学杂志（英文版）2012，Vol.125Issue(13)：2349-2360,12.DOI:10.3760/cma.j.issn.0366-6999.2012.13.020
Epigenetics of hepatocellular carcinoma: a new horizon
Epigenetics of hepatocellular carcinoma: a new horizon
LIU Wei-ren 1SHI Ying-hong 1PENG Yuan-fei 2FAN Jia1
作者信息
- 1. Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai 200032,China
- 2. Institute of Biomedical Sciences, Fudan University, Shanghai 200032. China
- 折叠
摘要
Abstract
Epigenetic changes refer to stable alterations in gene expression with no underlying modifications in the genetic sequence itself.It has become clear that not only gene variations but also epigenetic modifications may contribute to varied diseases,including cancer.This review will provide an overview of how epigenetic factors,including genomic DNA methylation,histone modifications,and miRNA regulation,contribute to hepatocellular carcinoma (HCC) dissemination,invasion,and metastasis.Additionally,the reversal of dysregulated epigenetic changes has emerged as a potential strategy for the treatment of HCC,and we will summarize the latest epigenetic therapies for HCC.关键词
hepatocellular carcinoma/epigenetic/DNA methylation/miRNAKey words
hepatocellular carcinoma/epigenetic/DNA methylation/miRNA引用本文复制引用
LIU Wei-ren,SHI Ying-hong,PENG Yuan-fei,FAN Jia..Epigenetics of hepatocellular carcinoma: a new horizon[J].中华医学杂志（英文版）,2012,125(13):2349-2360,12.
