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Association of estrogen receptor alpha gene polymorphisms with bone mineral density: a meta-analysis

WANG Ke-jie SHI Dong-quan SUN Li-sheng JIANG Xu L(U) Yan-yun DAI Jin CHEN Dong-yang XU Zhi-hong JIANG Qing

中华医学杂志（英文版）2012，Vol.125Issue(14)：2589-2597,9.

中华医学杂志（英文版）2012，Vol.125Issue(14)：2589-2597,9.DOI:10.3760/cma.j.issn.0366-6999.2012.14.034

Association of estrogen receptor alpha gene polymorphisms with bone mineral density: a meta-analysis

WANG Ke-jie ¹SHI Dong-quan ²SUN Li-sheng ³JIANG Xu ⁴L(U) Yan-yun ³DAI Jin ²CHEN Dong-yang ³XU Zhi-hong ⁴JIANG Qing³

作者信息

1. Department of Orthopaedics, Changzhou No. I People's Hospital,Changzhou, Jiangsu 213003, China
2. Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing, Jiangsu 210008, China
3. Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu 210061, China
4. Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing, Jiangsu 210008, China
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摘要

Abstract

Background A number of studies have examined the association between estrogen receptor alpha (ESR-α) gene polymorphisms and bone mineral density (BMD),but previous studies of ESR-α gene Xbal (rs9340799) and Pvull (rs2234693) polymorphisms have been hampered by small sample size,regional restrictions and inconclusive results.Thus a meta-analysis is needed to assess their pooled effects.üMethods This study reviewed all published articles indexed in Pubmed using the keywords in the title or abstract.All data were extracted independently by two reviewers using a standard form,the studies were mete-analyzed and minor discrepancies were resolved by authors' discussion.Results Twenty seven eligible studies involving 8467 women and 2032 men were identified.The Xbal and Pvull polymorphisms were significantly associated with BMD of the lumbar spine.XX and PP homozygotes had a protective effect in comparison with carriers of the x and p alleles,the effects were more significant in premenopausal women or Western women.At the femoral neck,the results were different.XX served as a protective factor in postmenopausal women,Western women,Western postmenopausal women,and men,while PP was likely to serve as a risk factor in Eastern women,Eastern postmenopausal women,and men.Conclusions The Xbal polymorphism is correlated to BMD at diverse skeletal sites.PP had a protective role for the lumbar spine but might be a risk factor for the femoral neck.

关键词

bone mineral density/Xbal/Pvull/polymorphisms/estrogen receptor alpha gene/meta-analysis

Key words

bone mineral density/Xbal/Pvull/polymorphisms/estrogen receptor alpha gene/meta-analysis

引用本文复制引用

WANG Ke-jie,SHI Dong-quan,SUN Li-sheng,JIANG Xu,L(U) Yan-yun,DAI Jin,CHEN Dong-yang,XU Zhi-hong,JIANG Qing..Association of estrogen receptor alpha gene polymorphisms with bone mineral density: a meta-analysis[J].中华医学杂志（英文版）,2012,125(14):2589-2597,9.

基金项目

This work was supported by National Natural Science Foundation of China (No.30973046). （No.30973046）

中华医学杂志（英文版）

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ISSN：0366-6999

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