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Fungal infection after a tragedy: a report of three cases of candidosis in a fire accident

PAN Wei-hua XIA Zhao-fan SHAN Hong-wei CHEN Min LIAO Wan-qing

中华医学杂志（英文版）2012，Vol.125Issue(14)：2628-2631,4.

中华医学杂志（英文版）2012，Vol.125Issue(14)：2628-2631,4.DOI:10.3760/cma.j.issn.0366-6999.2012.14.040

Fungal infection after a tragedy: a report of three cases of candidosis in a fire accident

PAN Wei-hua ¹XIA Zhao-fan ²SHAN Hong-wei ³CHEN Min ⁴LIAO Wan-qing⁴

作者信息

1. Shanghai Key Laboratory of Molecular Medical Mycology,Department of Dermatology, Institute of Dermatology and Medical Mycology ,Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2. Department of Bums, Changhai Hospital, Second Military Medical Univcrsity, Shanghai 200433, China
3. Department of Intensive Care Unit, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
4. Shanghai Key Laboratory of Molecular Medical Mycology,Department of Dermatology, Institute of Dermatology and Medical Mycology ,Changzheng Hospital, Second
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摘要

Abstract

Patients who suffer severe bums are at increased risk for local and systemic infections.The incidence of fungal infections has increased in recent years,and these infections represent a major issue in bum intensive care units.Herein,we report three cases of fungal infection due to Candida species occurring in patients undergoing supportive therapy and antibiotic treatment during their hospitalization.Two of these patients were infected with Candida parapsilosis,and one was infected with Candida albicans.The risk factors for these patients' Candida infections were multiple and prolonged courses of antimicrobial treatment,steroid treatment,tracheal intubation and smoke inhalation.Susceptibility testing of nine antifungal compounds was performed,and the minimum inhibitory concentration (MIC) values of all isolated strains were lower than the breakpoint MIC value for resistance of the relevant drug.All three patients were cured by treatment with antifungal agents.Candida infection may occur 1-3 weeks after thermal injury,and the prompt recognition and treatment of such infections with antifungal therapies may result in decreased morbidity and mortality associated with these infections in burn patients.

关键词

fungal infection/candidosis/burn

Key words

fungal infection/candidosis/burn

引用本文复制引用

PAN Wei-hua,XIA Zhao-fan,SHAN Hong-wei,CHEN Min,LIAO Wan-qing..Fungal infection after a tragedy: a report of three cases of candidosis in a fire accident[J].中华医学杂志（英文版）,2012,125(14):2628-2631,4.

基金项目

This work was partly supported by grants from the National Natural Science Foundation of China (No.30970130 and 80171335),the People's Liberation Army Clinical High-tech Major Projects Fund (No.2010gxjs063),and Shanghai Science and Technology Commission Fund (No.10dz2220100). （No.30970130 and 80171335）

中华医学杂志（英文版）

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ISSN：0366-6999

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