中华医学杂志（英文版）2012，Vol.125Issue(15)：2643-2648,6.DOI:10.3760/cma.j.issn.0366-6999.2012.15.001
Does urothelial cancer of bladder behave differently in young patients?
Does urothelial cancer of bladder behave differently in young patients?
摘要
Abstract
Background Bladder urothelial cancer has been diagnosed at an increasing rate among young adults in China while the clinical outcomes remain highly controversial.To optimize the management of young patients with bladder cancer,we examined whether bladder urothelial cancer in young patients behaved differently from that in the elder patients.Methods From 1994 to 2008,a database of bladder urothelial cancer patients at a major tertiary medical center was retrospectively reviewed.The clinical and pathological parameters of patients who were less than 40 years of age and a series of patients older than 40 years of age as the control group during the same period were compared.A survival analysis was performed using the Kaplan-Meier method and log-rank test,and Cox regression was performed to identify clinical parameters that affected the clinic outcomes.Results Young bladder cancer patients had a lower male-to-female ratio and were less likely to have advanced stages and high-grade cancers at the initial diagnosis.Tumors in young bladder cancer patients tended to be less multifocal at diagnosis.In addition,young patients had a lower recurrence rate and longer recurrence interval than older patients.The Kaplan-Meier curve and Log-rank test showed that young patients had significantly better cancer specific survival than old patients.The univariats and multivariate Cox regression analysis revealed that tumor grade is the sole predictor for tumor recurrence in young patients.Conclusions Young patients with bladder cancer have favorable pathological features and clinical outcomes than older patients.These findings argue for more conservative management approaches for young patients with bladder cancer.关键词
bladder cancer/young adults/pathology/prognosisKey words
bladder cancer/young adults/pathology/prognosis引用本文复制引用
WANG Zhi-hua,LI You-yuan,HU Zhi-quan,ZHU Hui,ZHUANG Qian-yuan,QI Yong,YE Zhang-qun..Does urothelial cancer of bladder behave differently in young patients?[J].中华医学杂志（英文版）,2012,125(15):2643-2648,6.基金项目
This project was supported by the grant from the Doloral Fund of the Ministry of Education of China (No.20090142120096). （No.20090142120096）
