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Neonatal ventral hippocampal lesion as a valid model of schizophrenia: evidence from sensory gating study

CHEN Xing-shi ZHANG Chen XU Yi-feng ZHANG Ming-dao LOU Fei-ying CHEN Chong TANG Jin

中华医学杂志（英文版）2012，Vol.125Issue(15)：2752-2754,3.

中华医学杂志（英文版）2012，Vol.125Issue(15)：2752-2754,3.DOI:10.3760/cma.j.issn.0366-6999.2012.15.018

Neonatal ventral hippocampal lesion as a valid model of schizophrenia: evidence from sensory gating study

CHEN Xing-shi ¹ZHANG Chen ²XU Yi-feng ²ZHANG Ming-dao ¹LOU Fei-ying ¹CHEN Chong ¹TANG Jin³

作者信息

1. Department of Electrophysiology, Shanghai Mental Health Center,Shanghai Jiao Tong University, Shanghai 200030, China
2. Department of Psychiatry , Chinese Academy of Sciences, Shanghai 200031, China
3. Laboratory of Shanghai Center for Life Sciences , Chinese Academy of Sciences, Shanghai 200031, China
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摘要

Abstract

Background The neonatal ventral hippocampal lesion (NVHL) rat model has been proposed as an experimental model for schizophrenia.NVHL rats display impaired central nervous system (CNS) inhibition,which may lead to a phenomenon similar to P50 sensory gating deficits observed in schizophrenic patients.In this study,we investigated whether sensory gating deficits occurred in the NVHL rat as a model for schizophrenia.Methods We created the NVHL rat model using ibotenate.The P20 and N40 were measured to assess sensory response and gating in NVHL and sham rats.Epidural electrodes recorded evoked potentials (EPs).from which latencies,amplitudes,difference scores (S1-S2),and gating ratios (S2/S1) were assessed.Results Compared with sham controls,prolonged S1 N40 latency and decreased S2 N40 amplitude were detected in the NVHL group.In neither difference scores nor gating ratios,a significant difference was found between NVHL group and sham controls.Conclusions NVHL rats may be a valid animal model for schizophrenia.This strategy will be useful in future neurobiological studies investigating the etiology of schizophrenia.

关键词

auditory evoked potentials/electroencephalography/sensory gating/schizophrenia/animal model

Key words

auditory evoked potentials/electroencephalography/sensory gating/schizophrenia/animal model

引用本文复制引用

CHEN Xing-shi,ZHANG Chen,XU Yi-feng,ZHANG Ming-dao,LOU Fei-ying,CHEN Chong,TANG Jin..Neonatal ventral hippocampal lesion as a valid model of schizophrenia: evidence from sensory gating study[J].中华医学杂志（英文版）,2012,125(15):2752-2754,3.

基金项目

This study was supported by the grants from the National Key Basic Research Science Foundation (973 Project,No.2010CB529605) and the National Natural Science Foundation of China (No.81000581 and No.30971046). （973 Project,No.2010CB529605）

中华医学杂志（英文版）

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ISSN：0366-6999

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