首页|期刊导航|中华医学杂志（英文版）|Protective effect of low potassium dextran solution on acute kidney injury following acute lung injury induced by oleic acid in piglets
中华医学杂志（英文版）2012，Vol.125Issue(17)：3093-3097,5.DOI:10.3760/cma.j.issn.0366-6999.2012.17.023
Protective effect of low potassium dextran solution on acute kidney injury following acute lung injury induced by oleic acid in piglets
Protective effect of low potassium dextran solution on acute kidney injury following acute lung injury induced by oleic acid in piglets
摘要
Abstract
Background Low potassium dextran (LPD) solution can attenuate acute lung injury (ALI).However,LPD solution for treating acute kidney injury secondary to ALI has not been reported.The present study was performed to examine the renoprotective effect of LPD solution in ALI induced by oleic acid (OA) in piglets.Methods Twelve animals that suffered an ALI induced by administration of OA into the right atrium were divided into two groups:the placebo group (n=6) pretreated with normal saline and the LPD group (n=6),pretreated with LPD solution.LPD solution was injected intravenously at a dose of 12.5 ml/kg via the auricular vein 1 hour before OA injection.Results All animals survived the experiments with mild histopathological injury to the kidney.There were no significant differences in mean arterial pressure (MAP),creatinin and renal damage scores between the two groups.Compared with the placebo group,the LPD group had better gas exchange parameters at most of the observation points ((347.0±12.6)mmHg vs.(284.3±11.3) mmHg at 6 hours after ALI,P＜0.01).After 6 hours of treatment with OA,the plasma concentrations of NGAL and interleukin (IL)-6 in both groups increased dramatically compared to baseline ((6.0±0.6) and (2.50±0.08) folds in placebo group; and (2.5±0.5) and (1.40±0.05) folds in LPD group),but the change of both parameters in the LPD group was significantly lower (P ＜0.01) than in the placebo group.And 6 hours after ALl the kidney tissue concentration of IL-6 in the LPD group ((165.7 ± 22.5) pg.ml-1.g-1 protein) was significantly lower (P ＜0.01) than that in placebo group ((67.2± 25.3) pg.ml-1.g-1 protein).Conclusion These findings suggest that pretreatment with LPD solution via systemic administration might attenuate acute kidney injury and the cytokine response of IL-6 in the ALl piglet model induced by OA injection.关键词
low potassium dextran solution/ acute kidney injury/ acute lung injury/ interleukin-6/ pigletKey words
low potassium dextran solution/ acute kidney injury/ acute lung injury/ interleukin-6/ piglet引用本文复制引用
WU Rui-ping,LIANG Xiu-bin,GUO Hui,ZHOU Xiao-shuang,ZHAO Li,WANG Chen,LI Rong-shan..Protective effect of low potassium dextran solution on acute kidney injury following acute lung injury induced by oleic acid in piglets[J].中华医学杂志（英文版）,2012,125(17):3093-3097,5.基金项目
This work was supported by grants from the National Natural Science Foundation of China (No.30971380 and No.31071026),and by the National Excellent Doctoral Dissertation of China. （No.30971380 and No.31071026）
