中华临床免疫和变态反应杂志2012，Vol.6Issue(3)：173-176,4.
类风湿关节炎患者血清白细胞介素-4水平与间质性肺疾病的关系
Relationship between the Level of Interleukin- 4 Expression in Serum of Rheumatoid Arthritis Patients with Interstitial Lung Disease
摘要
Abstract
Objective To invesLigaLe Lhe acLion and correlaLion of inLerleukin-4 ( 1L-4 ) vviLh Lhe paLhogenesis of rheumaLoid arLhriLis( RA )and rheumaLoid arLhriLis relaLed inLersLkial lung diseases ( 1LD ). Methods SixLy-Lvvo palienLs vviLh RA were divided inLo Lvvo groups, 31 eases vviLh simple RA group and 31 RA paLienLs eomplieaLed vviLh ILL) ( RA + 1LD group ). AnoLher 30 heakhy suhjeeLs were included as Lhe conLrol group. Enzyme linked immunosorhenL assay ( EL1SA ) was used Lo dcLccL Lhe serum levels of IL-4 in 62 paLienLs vvkh RA ( 31 cases vviLh simple RA and 31 cases vviLh 1LD ) and 30 heakhy conLrols, laboratory indexes including IgG, IgA, IgM, γ-globlin( 7-G ), rhoumaLoid facLor( RF ), erylhrocyLe sedimenLaLion raLe ( ESR ), C reacLive proLein( CRP ) as well as Lhe number of Lender joinLs were compared in each group and all daLa were processed Lo carry ouL Lhe relevance analysis. Results The level of IL-4 in paLienLs vviLh RA ( 61. 87 ±41. 36 )pg/ml was significanLly higher Lhan lhal of Lhe conLrol group( 25. 48 ± 14. 28 )pg/ml( P ＜ 0. 05 ), while Lhe IL-4 level of Lhe RA + ILD group( 92. 70 ±32. 01 )pg/ml was significanLly higher Lhan lhal of Lhe simple RA group( 30. 05 ±24. 45 )pg/ml ( P ＜0. 05 ). Conclusion IL-4 may play an imporLanL mle in the pathogenesis of RA, and may contribute to the progression of lung fibrosis in RA patients.关键词
白细胞介素-4/类风湿关节炎/间质性肺疾病Key words
interleukin-4/ rheumatoid arthritis/ interstitial lung disease分类
医药卫生引用本文复制引用
杨春萍,李晓琳,林填田,齐晨月,鲁静..类风湿关节炎患者血清白细胞介素-4水平与间质性肺疾病的关系[J].中华临床免疫和变态反应杂志,2012,6(3):173-176,4.基金项目
国家自然科学基金(81172867),辽宁省教育厅高校科研基金(L2010613) （81172867）
