中华临床免疫和变态反应杂志2012，Vol.6Issue(3)：210-214,5.
流感疫苗接种后出现关节炎2例并文献复习
Arthritis Caused by Influenza A H1N1 Vaccines: Case Report and Literature Review
冷晓梅 1尹晶 2田新平1
作者信息
- 1. 中国医学科学院,北京协和医学院,北京协和医院风湿免疫科,北京,100032
- 2. 天津市儿童医院风湿免疫科,天津 300074
- 折叠
摘要
Abstract
Objective To investigate the relationship between inherent susceptibility and arthritis after influenza A H1N1 vaccination. Methods Two cases were described and the clinical and HLA-DR4 genotype characterisitics were analyzed. Rheumatoid factor was detected with immune turbidimetry, AFP/AKA and ANA were tested with indirect immunoinfluscent assay( IFA ), and anti-CCP was tested with enzyme linked immunosorbent assay( ELISA ). HLA-DR4 was tested by polymerase chain reaction( PCR ) amplification. Results These two patients who developed arthritis after HI Nl vaccination were both females. One arthritis was temporary and HLA-DR4 was negative. The other developed rheumatoid arthritis and was HLA-DR4 positive. Conclusion The inherent background may play an important role in developing rheumatoid arthritis after vaccination.关键词
H1N1流感疫苗/关节炎/组织相容性抗原DR4Key words
influenza vaccines, H1N1/ arthritis/ HLA-DR4分类
医药卫生引用本文复制引用
冷晓梅,尹晶,田新平..流感疫苗接种后出现关节炎2例并文献复习[J].中华临床免疫和变态反应杂志,2012,6(3):210-214,5.
