针灸临床杂志2012，Vol.28Issue(7)：52-54,3.
针刺对神经干细胞海马内移植痴呆大鼠学习记忆和脑内胆碱能系统的影响
Observing the Effect of Acupuncture on Metabolism of Study Memorizing Ability and the Quantity of AchE System in Brain of AD Rats
摘要
Abstract
Objective :To observe the effect of acupuncture on the study of memori - zing ability and the quantity of AchE system in brain of AD rats of neural stem cell transplantation of hippocampus and discuss the mechanism of acupuncture cure the AD. Methods:The model was made by injecting p - AP to CA1 of hippocampus, the rats were randomly divided into normal group, model group, transplantal group, acupunctural group and transplantal acupuncture group, each group has 12 cases. Baihui,dazhui and renzhong point were selected for the acupuncture group which were connected by the electronic needle device. The memorizing ability was measured by using the diving tower of rats and enzyme - immunossay methods in cerebral cortex, the content of hipp-ocamous ChAT was examined by ELISA method. Results: The reaction period of step down and the times of memory in transplantal acupuncture decrease(P <0.05) than the model group, and the quantity of ChAT in cerebral cortex and hippocampus of the transplantal acupuncture group increase (P < 0. 05) than the model group. There are obvious differences between the transplantal acupuncture group and the transplantal group ( P < 0.05). Conclusion: The quantity of AchE system in brain of AD rats can be improved by acupuncture and acupuncture combined with transplant of Neural stem cell has better treatment effect.关键词
老年性痴呆/神经干细胞/海马/胆碱乙酰转移酶Key words
Alzheimer's disease/ Neural stem cell/ Hippocampus/ ChAT分类
医药卫生引用本文复制引用
杨春壮,徐永良,陆迪,马彦文,关艳中,赵微..针刺对神经干细胞海马内移植痴呆大鼠学习记忆和脑内胆碱能系统的影响[J].针灸临床杂志,2012,28(7):52-54,3.基金项目
黑龙江省自然科学基金项目,编号:D200664 （）
黑龙江省卫生厅医学科研课题,编号:2006-401. （）
