肿瘤防治研究2012，Vol.39Issue(7)：769-772,4.DOI:10.3971/j.issn.1000-8578.2012.07.002
回药爱康方抗C57小鼠肺癌转移及影响bcl-2的表达
Effects of Hui Medicine Aikangfang on Metastasis and bcl-2 Expression of Lung Cancer in C57 Mice
摘要
Abstract
Objective To observe meiastatic effect of Hui medicine Aikangfang in C57 mice Lewis lung cancer cells and test bcl-2 expression in each mice tumor tissue. Methods Fifty-five tumor-bearing mice were randomly divided into model group, chemotherapy ( CTX) group. low-dose group, low-dose with chemotherapy group and high-dose with chemotherapy group. After treatment, observing the lung surfaces metastasis and bcl-2 protein expressions of each mouse. Results ( 1) Lung metastases changes : compared with tumor-bearing model,the more than mice lung metastases is statistically significant difference (P<0. 05). (2) bcl-2 expression : compared with tumor-bearing model, the more than bcl-2 expression is statistically significant difference (P<0. 01). Conclusion Hui medicine Aikangfang can resist lung cancer metastasis in mice and reduce bcl-2 expression.关键词
回药爱康方/lewis肺癌/bcl-2蛋白Key words
Aikangfang decoction/Lewis lung carcinoma/bcl-2 protein分类
医药卫生引用本文复制引用
马科,马治国,龙一梅,周丽萍,楚国庆,边静,周慧..回药爱康方抗C57小鼠肺癌转移及影响bcl-2的表达[J].肿瘤防治研究,2012,39(7):769-772,4.基金项目
国家自然科学基金资助项目(81160462) （81160462）
教育部春晖课题(Z2007-1-750004) （Z2007-1-750004）
宁夏回族自治区科技攻关课题[(2008)80] （2008）
