肿瘤防治研究2012，Vol.39Issue(7)：784-786,3.DOI:10.3971/j.issn.1000-8578.2012.07.006
CXCRl/CXCR2受体拮抗剂-G31P抑制前列腺癌血管新生的体内实验
Inhibition of G31P : Chemokine Receptor CXCR1/CXCR2 Antagonist, in Angiogenesis of Human Prostate Cancer Cells in vivo
刘欣 1戴晓冬 2李星云 1王晓丽 1李芳3
作者信息
- 1. 116044辽宁大连,大连医科大学微生物学教研室
- 2. 116044辽宁大连,大连医科大学寄生虫学教研室
- 3. 116044辽宁大连,大连医科大学免疫学教研室
- 折叠
摘要
Abstract
Objective To investigate the inhibition of G31P on the angiogenesis of the prostate cancer PC-3 cell in vivo. Methods The effect of G31P on angiogenesis of human prostate tumor of nude mice were observed in nude mice by building a human androgen-independent prostate cancer PC-3 (GFP-labeled) or-thotopic transplantation tumor cells model. Results The tumor angiogenesis of G31P treated group (1. 26 ±0.46)was significantly reduced (0. 49±0. 12,P<0. 05) compared with the control group. VEGF(P< 0. 01) and NF-KB(P<0. 01) expression of G31P treated groupwas significantly reduced (immunohisto-chemistry) compared with the control group. Conclusion G31P could inhibit the angiogenesis of the prostate cancer PC-3 cell in vivo.关键词
G31P/前列腺癌/血管新生/CXCR1/CXCR2Key words
G31P/Prostate cancer/ Angiogenesis/CXCRl /CXCR2
分类
医药卫生引用本文复制引用
刘欣,戴晓冬,李星云,王晓丽,李芳..CXCRl/CXCR2受体拮抗剂-G31P抑制前列腺癌血管新生的体内实验[J].肿瘤防治研究,2012,39(7):784-786,3.
