肿瘤防治研究2012，Vol.39Issue(7)：807-810,4.DOI:10.3971/j.issn.1000-8578.2012.07.011
乳腺导管内增生性病变中Skp2和p27kip1的表达及意义
Significance of Expression of Skp2 and p27kipl in Intraductal Proliferative Lesions in Breast
吕艳 1牛昀 2丁秀敏 2肖旭祺2
作者信息
- 1. 300193天津,天津中医药大学第一附属医院病理科
- 2. 天津医科大学附属肿瘤医院乳腺病理研究室
- 折叠
摘要
Abstract
Objective To explore the relationship of abnormal expression of Skp2 and p27kipl between in-traductal proliferation lesions and breast cancer. Methods The positive expression ratio of Skp2 protein and p27kipl protein in 30 cases of normal control group, 120 cases of intraductal proliferation lesions including 30 cases of usual ductal hyperplasia(UDH) ,30 cases flat epithelial atypia(FEA) ,30 cases of atypical ductal hyperplasia( ADH) and 30 cases of ductal carcinoma in situ(DCIS) were detected using immu-nohistochemical method. Results The positive expression ratio of Skp2 in four subtypes were all higher than that in normal control (P<0. 05). The positive expression ratio of Skp2 protein of DC'IS.FEA and ADH were higher than that of UDH. There were significant difference between DCIS.FEA and ADH(P <0. 05). The positive expression ratio of p27Kipl in four subtypes were all lower than that in normal control (P"). 05). Remarkable difference of expression ratio of p27kipl existed between UDH and DOS (P<0. 05), FEA and DCIS (P<0. 05), ADH and DCIS (P< 0. 05). Skp2 protein level was reversely correlated with p27kipl protein level overall(r= - 0. 411 ,P = 0. 000). The same results existed in UDH and DCIS,respectively(r= - 0. 406,P = 0. 026;r= - 0. 544,P = 0. 002). Conclusion The increase of expression level of Skp2 protein and decrease of expression level of p27kipl protein have closed association with dysplasia of breast ductal epithelial and development of breast cancer.关键词
乳腺癌/导管内增生性病变/细胞周期调控/Skp2/泛素蛋白/p27kip1Key words
Breast cancers Intraductal proliferation lesionssCell cycle regulation/Skp2/Ubiquitin/p27kipl
分类
医药卫生引用本文复制引用
吕艳,牛昀,丁秀敏,肖旭祺..乳腺导管内增生性病变中Skp2和p27kip1的表达及意义[J].肿瘤防治研究,2012,39(7):807-810,4.
