肿瘤防治研究2012，Vol.39Issue(7)：838-840,3.DOI:10.3971/j.issn.1000-8578.2012.07.018
高龄局部进展期食管癌患者术前新辅助放化疗的安全性和疗效观察
Study on Neoadjuvant Chemoradiation for Elderly Patients with Local Advanced Esophageal Squamous Carcinomas
务森 1陈明耀 1雒建超 2魏立 1陈重1
作者信息
- 1. 450003郑州,河南省人民医院胸部肿瘤中心
- 2. 450003郑州,河南省人民医院放疗科
- 折叠
摘要
Abstract
Objective To evaluate the safety and efficacy of neoadjuvant chemoradiation for elderly patients (age≥70) with local advanced esophageal squamous carcinomas. Methods A total 27 elder patients staged cT3N0~1 (group A) were analyzed retrospectively compared with 62 cases of younger patients (group B),all of them were given 2 cycles cisplatin 75 mg/m2 plus fluorouracil 600 mg/nr dl~5 and 40 Gy of radiation followed by surgery 3 ~4 weeks later in past two years. Results All patients accomplished planned neoadjuvant chemoradtations. Neoadjuvant chemoradiation caused vomiting, neutropenia and esophagitis in two arms similarly,only G3/4 neutropenia occurred in 25. 9% (7/27) of group A versus 8. l%(5/62) of group B (P = 0.023). The effective rate of neoadjuvant chemoradiation was 92. 6% (25/ 27) in group A vs. 95. 2% in group B (P= 0. 621), 88. 0% patients (24/27)underwent complete resection of group A and 87. 1 % (54/62) of group B (P = 0. 563). No mortality was found. The overall complication rate were similar in two groups (32.0% vs. 22. 0)%), Arrhythmia,pneumonia and injury of recurrent la-ryngeal nerve were the common complications after surgery. The incidence of arrhythmia in group A occurs was 32. 0% contrast to 8. 5% in group B (P = 0.015). There was no difference of pCR between two groups (25. 9% vs. 22. 6% ). Conclusion There was no significant difference between elderly patients and younger patients with local advanced esophageal squamous carcinomas treated by neoadjuvant chemoradiation followed by surgery,though increased G3/4 neutropenias and arrhythmias. The neoadjuvant chemoradiation was safety and effective for elderly patients.关键词
食管癌/新辅助放化疗/外科治疗/高龄患者Key words
Esophageal carcinoma/Neoadjuvant chemoradiation/Surgery/Elderly patients
分类
医药卫生引用本文复制引用
务森,陈明耀,雒建超,魏立,陈重..高龄局部进展期食管癌患者术前新辅助放化疗的安全性和疗效观察[J].肿瘤防治研究,2012,39(7):838-840,3.
