肿瘤防治研究2012，Vol.39Issue(7)：851-854,4.DOI:10.3971/j.issn.1000-8578.2012.07.022
紫杉醇联合顺铂同步放化疗治疗中晚期食管癌的Meta分析
A Meta Analysis of Concurrent Radiotherapy Plus Paclitaxel and Cisplatin in Treatment of Esophageal Cancer
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of paclitaxel plus cisplatin chemotherapy combining concurrent radiotherapy on esophageal carcinoma. Methods We searched PubMed,EMBASE, Cochrane Library,CNKI.and other databases to collect randomized controlled trials (RCTs). According to the statistical analysis of RevMan5. 0 statistical software. Results The results were included in six randomized controlled trials,including 559 cases of patients. Meta analysis showed that in the treatment of advanced esophageal carcinoma,when compared with radiotherapy alone.the concurrent radiotherapy and chemotherapy can improve the efficiency, the RR value and 95% confidence interval were 1. 28(1. 17, 1. 40) and 1,2 or 3-year survival rate of RR values and 95% confidence interval are 1. 25(1. 10,1. 42), 1. 44(1. 18,1. 76) ,1. 46( 1. 15,1. 86) .respectively. However,the toxicities also increased.such as the incidence of radioactive esophagitis and gastrointestinal adverse reactions were 2. 49 (1. 02, 6. 08), 25. 00 (3. 49,179. 25), respectively. Conclusion The efficacy of pacli taxol plus cisplatin combined with concurrent radiotherapy on esophageal carcinoma is more effective than that of concurrent radiotherapy alone. Although the adverse reactions are increased at the same time,most of them can be tolerated.关键词
紫杉醇/顺铂/食管癌/单纯放疗/Meta分析Key words
Taxol/Cisplatin/Esophageal carcinoma/Radiotherapy/Meta analysis分类
医药卫生引用本文复制引用
尹雪,刘杰,田金徽..紫杉醇联合顺铂同步放化疗治疗中晚期食管癌的Meta分析[J].肿瘤防治研究,2012,39(7):851-854,4.基金项目
2011年度兰州大学中央高校基本科研业务费专项资金资助(lzujbky-2011-133) （lzujbky-2011-133）
