中山大学学报（自然科学版）2012，Vol.51Issue(4)：144-146,3.
3-溴-2-羟亚胺基-丙酸乙酯及其衍生物的合成
The Synthesis of Ethyl Hydroxyimino-bromopropanoate and Its Derivatives
摘要
Abstract
Ethyl-hydroxyimino-bromopropanoate was prepared from ethyl lactate, NBS and hydroxyla-mine hydrochloride in a novel method. In the reaction process, intermediate ethyl bromopyruvate was ob tained by bromination and oxidation, instead of being separated from the reaction mixture and directly used to react with hydroxylamine hydrochloride in CHCl3 and CH3OH solution. The white crystal product was obtained in 48% yield. The new derivative ethyl-3-bromo-2- ( 1-naphthoyl-oximino) propanoate was synthesized successfully via the mild esterification reaction. The target compound was characterized by 'HNMR, 13C-NMR and elemental analysis.关键词
溴代丙酮酸乙酯/3-溴-2-羟亚胺基-丙酸乙酯/合成Key words
ethyl bromopyruvate/ethyl hydroxyimino-bromopropanoate/synthesis分类
化学化工引用本文复制引用
宋健,林永成,陈荣礼..3-溴-2-羟亚胺基-丙酸乙酯及其衍生物的合成[J].中山大学学报（自然科学版）,2012,51(4):144-146,3.基金项目
广东省科技计划资助项目(2010B060900084) （2010B060900084）
中国博士后基金资助项目([2010]07) （[2010]07）
广东药学院博士启动基金资助项目(2006YKX11) （2006YKX11）
