中国中西医结合杂志2012，Vol.32Issue(5)：628-632,5.
大肠癌中医证型与ERCC1基因多态性的相关研究
Study of the Correlation between the Colorectal Cancer Chinese Medicine Syndrome Types and (excision repair cross-complementing 1, ERCC1 ) Gene Polymorphisms
摘要
Abstract
Objective To explore the correlation between excision repair cross-complementing 1 (ERCC1) C8092A and C19007T gene polymorphisms and different Chinese medicine (CM) syndrome types of colorectal cancer (CC). Methods Ninety-nine patients with CC were syndrome typed as dampness-heat accumulation syndrome, qi stagnation with blood stasis syndrome, Pi-Shen yang deficiency syndrome, and Gan-Shen yin deficiency syndrome. The gene polymorphisms of excision repair cross-complementing 1 (ERCC1) C8092A and C19007T in different CM syndrome types of CC were examined by polymorphisms chain reaction amplification and direct sequencing, and analyzed statistically. Results The frequencies of C8092A genotype and allele in different CM syndrome types had no statistical difference (P>0.05). The frequencies of C19007T genotype and allele in different CM syndrome types had statistical difference (P<0.05). Of them, there was no statistical difference in the frequencies between dampness-heat accumulation syndrome and qi stagnation with blood stasis syndrome, or between Pi-Shen yang deficiency syndrome and Gan-Shen yin deficiency syndrome (P>0.05). There was statistical difference between dampness-heat accumulation syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P<0.05). There was statistical difference between qi stagnation with blood stasis syndrome and Pi-Shen yang deficiency syndrome as well as Gan-Shen yin deficiency syndrome (P<0.05). Conclusion ERCC1 C19007T gene polymorphisms might be associated with CM syndrome types of CC, which needed to be further studied.关键词
大肠癌/中医证型/核苷酸切除修复交叉互补基因1/基因多态性Key words
colorectal cancer/ Chinese medicine syndrome type/ excision repair cross-complementing 1/ gene polymorphism引用本文复制引用
崔同建,陈义乾,戴永美,蒋云林,陈峥,张桂枫..大肠癌中医证型与ERCC1基因多态性的相关研究[J].中国中西医结合杂志,2012,32(5):628-632,5.基金项目
福建省科学技术厅资助项目(No.2006Y0010) （No.2006Y0010）
