中国中西医结合杂志2012，Vol.32Issue(7)：902-905,4.
康莱特联合吉西他滨三维适形同步放化疗治疗局部晚期胰腺癌临床观察
Curative Effect of 3D-CRT Combined with Gemcitabine Concurrently with Addition of Kanglaite Injection in Treatment of Locally Advanced Pancreatic Carcinoma
摘要
Abstract
Objective To explore the efficacy of concurrent chemoradiotherapy combined with Kanglaite Injection (Kl) for locally advanced pancreatic carcinoma patients. Methods Totally 50 patients unsuitable for surgery were randomly assigned to the treatment group and the control group, 25 in each group. Patients in the control group were treated with gemcitabine and concurrent 3D-CRT, while those in the treatment group were also treated with intravenous injection of Kl (at 100 mL7d) for 21 successive days, 28 days as one cycle, two cycles with one week interval. The short-term curative effect, the survival time, the improvement of symptoms, the tumor markers, and adverse reactions were respectively observed for two years. Results The short-term curative effective rate (CR + PR) was 52.17% (12/23), and the disease control rate (CR + PR +SD) was 95. 65% (22/23) in the treatment group. The short-term curative effective rate (CR + PR) was 41. 67% (10/24), and the disease control rate (CR + PR+SD) was 87.50% (21/24) in the control group. There was no statistical difference between the two groups (P>0.05). The 2-year survival rate was 34.78% (8/23) in the treatment group, better than that in the control group (25.00%, 6/24). The median survival time was 17.2 months in the treatment group and 12.4 months in the control group with statistical difference (P<0.05). The response rate of pain relief and weight gain were 75. 00% and 82. 61% in the treatment group respectively, and they were 50.00% and 54. 67% in the control group respectively, showing statistical difference between the two groups (P<0. 05). After treatment, the levels of CA19-9 (U/mL) and CEA (ng/mL) were respectively reduced to 118. 00 ±78. 89 and 7.41 ±2.37 respectively in the treatment group, showing statistical difference when compared with those of the control group (being 216. 00 ±153.23 and 12.25 ±7.53 respectively, P<0.05). Conclusion The concurrent chemoradiotherapy com- bined with Kl for locally advanced pancreatic carcinoma patients obtained better results.关键词
晚期胰腺癌/康莱特/吉西他滨/同步放化疗/三维适形放疗Key words
advanced pancreatic carcinoma/ Kanglaite Injection/ gemcitabine/ concurrent chemoradio-therapy/ 3D-CRT引用本文复制引用
沈伟生,舒中琴,邓立春,曹向明,奚蕾,张瑶,曾洁,盛华明,高春恒..康莱特联合吉西他滨三维适形同步放化疗治疗局部晚期胰腺癌临床观察[J].中国中西医结合杂志,2012,32(7):902-905,4.基金项目
江苏省卫生厅医学科技发展基金会临床肿瘤学基金项目(No.P200947) （No.P200947）
