中国中西医结合杂志2012，Vol.32Issue(7)：944-947,4.
甘草次酸对大鼠心室肌细胞钠离子通道电流的影响
Effects of Glycyrretinic Acid on Sodium Ion Channel Currents of Rats' Ventricular Myocardial Cells
摘要
Abstract
Objective To study the effects of glycyrretinic acid (GA) on the sodium ion channel currents (lNa) of rats' ventricular myocardial cells, and to explore its anti-arrhythmic mechanisms at the ion channel level. Methods Single ventricular myocardial cells was isolated from SD rats. The whole cell patch clamp was used to record the effects of GA on lNa of rats' ventricular myocardial cells. Results GA could inhibit lNa of rats' ventricular myocardial cells dose-dependently. GA at 1, 5, and 10 μmol/L decreased lNa of rats' ventricular myocardial cells from ( -4. 26 ±0. 15) nA to ( -3. 54 ±0. 10) nA, ( -2.19 ±0. 09) nA, and ( -1. 25 ±0. 08) nA, respectively. GA at 1, 5, and 10 μmol/L inhibited lNa by 16. 08% ±2. 3%, 50. 82% ±3. 56%, and 75. 98% ±5. 12%, showing statistical difference when compared with the control group (P<0. 05). GA at 10 μmol/L shifted lNa current-voltage curve more positively, but the activation potential and the peak potential were not changed. Conclusion GA inhibited the lNa of rats' ventricular myocardial cells dose-dependently, which was possibly associated with its anti-arrhythmia effects.关键词
甘草次酸/膜片钳/钠通道/心肌细胞Key words
glycyrretinic acid/ patch clamp/ sodium channel/ myocardial cell引用本文复制引用
杨继媛,吴红金,吴德琳..甘草次酸对大鼠心室肌细胞钠离子通道电流的影响[J].中国中西医结合杂志,2012,32(7):944-947,4.基金项目
国家自然科学基金资助项目(No.30873234) （No.30873234）
北京中医药重点学科项目(No.京中重312) （No.京中重312）
