中国中西医结合杂志2012，Vol.32Issue(8)：1038-1041,4.
慢性无症状HBV携带者阴虚体质与人类白细胞抗原-DRB1、DQA1基因多态性的联系
Study on the Correlation between Chronic Asymptomatic HBV Carriers of Yin Asthenia Constitution and Genotypes of HLA-DRB1and HLA DQA1Alleles
摘要
Abstract
Objective To study on the correlation between chronic asymptomatic HBV carriers (ASC) of yin asthenia constitution and genotypes of HLA-DRB1 and HLA DQAt alleles. Methods Totally 105 ASC were assigned to two groups according to their constitutions, i. e. , the yin asthenia group (47 cases) and the non-yin asthenia group (58 cases). The genotypes of HLA-DRB1 and HLA DQA1 alleles were determined using PCR-SSP. Results The gene frequency of HLA-DRB1 * 09 allele and HLA-DQA1 * 0301 aliele (being 12. 1 % and 19. 1%) were obviously lower in the yin asthenia group than in the non-yin asthenia group (being 27. 8% and 39. 7%, P<0. 05). The gene frequency of HLA-DRB1 * 11 allele and HLA-DQA1 * 0501 allele were obviously higher in the yin asthenia group (being 12. 1% and 28. 7%) than in the non-yin asthenia group (4. 3% and 9. 5%), showing statistical difference ( P < 0. 05, P < 0. 01 ). Conclusions HLA-DRB1 * 09 allele and HLA-DQA1 *0301 allele might be the molecular bases for non-yin asthenia patients with ASC. HLA-DRB1 * 11 allele and HLA-DQA1 * 0501 allele might be the molecular bases tor yin asthenia patients with ASC.关键词
慢性无症状HBV携带者/阴虚体质/基因多态性Key words
chronic asymptomatic HBV carrier/ yin asthenia constitution/ polymorphism of gene引用本文复制引用
过建春,肖丽娜,荀运浩,王宇芳,李春青,石伟珍,施军平..慢性无症状HBV携带者阴虚体质与人类白细胞抗原-DRB1、DQA1基因多态性的联系[J].中国中西医结合杂志,2012,32(8):1038-1041,4.基金项目
浙江省中医药科技计划项目(No.2009WA010) （No.2009WA010）
