中国中西医结合杂志2012，Vol.32Issue(8)：1042-1045,4.
益气通络解毒降浊方结合西医基础疗法治疗早、中期慢性肾功能衰竭疗效观察
Efficacy Observation of Treating Early and Midterm Chronic Renal Failure Patients by Qi Supplementing,Collateral Dredging, Detoxifying, and Turbidity Descending Recipe Combined with Basic Methods of Westem Medicine
摘要
Abstract
Objective To observe therapeutic efficacy of treating early and midterm chronic renal failure (CRF) patients by Qi Supplementing, Collateral Dredging, Detoxifying, and Turbidity Descending Recipe (QSC-DDTDR) combined with basic methods of Western medicine (WM). Methods Totally 160 early and midterm CRF patients were recruited from Hebei Hospital of Traditional Chinese Medicine, Hebei Medical University from January 2007 to December 2011. They were randomly assigned to the treatment group and the control group, 80 in each group. On the basis of basic treatment of WM, QSCDDTDR was given to patients in the treatment group, while Niaoduqing Granule (NDQG) was given to those in the control group. After 12 months of treatment, the therapeutic efficacy, Chinese medicine (CM) symptom scores, serum creatinine (SCr), blood urine nitrogen (BUN), 24 h urine protein quantitation, hemoglobin (Hb), and the occurrence of end-point events were ob-served. Results The total effective rate in the treatment group was 77. 6% (28/76), obviously higher than that in the control group [(58. 1%, 43/74), P < 0. 05 ]. After treatment the CM syndrome scores obviously de-creased in the treatment group (18. 3 ±5. 3), obviously lower than before treatment (26. 0 +4. 4) and the control group (22. 4 ±4. 9) (P<0. 05, P <0. 01). The levels of SCr, BUN, and 24 h urine protein quantitation were (169.1 ±22. 6) μmol/L, (10. 4 ±2. 0) mmol/L, (861. 4 ±232. 7) mg/24 h, respectively, in the treatment group after treatment, which were lower than before treatment [(204.1 ±27.7) umol/L, (13.2 ±3.2) mmol/L, (1 287. 5 ±442. 3) mg/24 h, P<0. 01). The aforesaid indices were also improved in the control group after treatment (P<0. 05, P<0. 01). The decrease in SCr, BUN, and 24 h urine protein quantitation after treatment was more obviously in the treatment group than in the control group [(185. 8 ±23. 9) pmol/L, (11.2 ±2. 5) mmol/L, (1 014. 5 ±301. 7) mg/24 h; P <0. 05, P<0. 01). The incidence rate of the end-point events was 10. 53% (8/76) in the treatment group and 13. 51% (10/74) in the control group, but with no statistical differ-ence. Conclusion QSCDDTDR combined with basic methods of WM showed better therapeutic efficacy in impro-ving the renal function and reducing the level of urinary protein of the early and midterm CRF patients.关键词
益气通络解毒降浊方/早、中期慢性肾衰竭/中医症状积分/终点事件Key words
qi supplementing, collateral dredging, detoxifying, and turbidity descending recipe/ early and midterm chronic renal failure/ Chinese medicine symptom score/ end-point event引用本文复制引用
郭立芳,王凤丽,王月华,张丽红,林琼真,康丽霞,陈志强..益气通络解毒降浊方结合西医基础疗法治疗早、中期慢性肾功能衰竭疗效观察[J].中国中西医结合杂志,2012,32(8):1042-1045,4.基金项目
“十一五”国家科技支撑计划重点项目(No.2007BAI1OB01-008) （No.2007BAI1OB01-008）
河北省中医药管理局科学技术研究与发展计划项目(No.2009022) （No.2009022）
