中药材2012，Vol.35Issue(5)：744-749,6.
竹节参总皂苷预处理对冠脉结扎致大鼠急性心肌缺血损伤的影响
Effects of Total Saponin from Panax japonicus on Acute Myocardial Ischemia Injury Induced by Ligating Coronary Artery Left Anterior Descending Branch in Rats
摘要
Abstract
Objective: To investigate the cardioprotective effects of total saponin from Panax japonicus pretreating on acute myocardial ischemia injury induced by ligating coronary artery left anterior descending branch ( LAD) in rats. Methods:Rats were divided into sham group, model group and total saponin group. The treatment group was given total saponin of Panax japonicus. After pretreating for 7 days,the rats' acute myocardial ischemia model was induced by LAD. The electrocardiogram,hemodynamics,infarct size and histo-morphology were assessed 12h after LAD, the serum levels of phosphokinase (CK), lactate dehydrogenase ( LDH), superoxide dis-mutase (SOD) ,catalase (CAT) and malondialdehyde (MDA) were also measured. Results:Compared with the model group,total saponin from Panax japonicus significantly improved heart function, heart histomorphology, opposed ECG T wave decreased and decreased infarct size ; Remarkably decreased the contents of LDH , CK and MDA , increased the activity of SOD , CAT. Conclusion : Total saponin from Panax japonicus has cardioprotective effects on acute myocardial ischemic injury and the mechanism may be related to antioxidation.关键词
竹节参/总皂苷/急性心肌缺血/保护作用Key words
Panax japonicus C. A. Mey. /Total saponin/Acute myocardial ischemia/ Cardioprotective effects分类
医药卫生引用本文复制引用
贺海波,袁丁,许佳,徐媛青,王洪武,狄国杰,李守超,孙志伟,何毓敏,张长城..竹节参总皂苷预处理对冠脉结扎致大鼠急性心肌缺血损伤的影响[J].中药材,2012,35(5):744-749,6.基金项目
国家自然科学基金(31070314 （）
30873383) （）
