中药材2012，Vol.35Issue(5)：765-769,5.
石斛合剂对2型糖尿病模型大鼠的降糖作用及其对胰岛细胞凋亡的影响
Effect of Dendrobium Mixture on Hypoglycemic and the Apoptosis of Islet in Rats with Type 2 Diabetic Mellitus
黎同明 1邓敏贞1
作者信息
- 1. 广州中医药大学中药学院,广东广州510006
- 折叠
摘要
Abstract
Objective:To study the effect of Dendrobium mixture on hypoglycemic and the apoptosis of islet in rats with type 2 diabetic mellitus. Methods:Type 2 diabetes mellitus models were induced by high sugar and fat diet and low dose intraperitoneal injection of streptozotocin(STZ) in rats,and treated with Dendrobium mixture(5,10,20 g/kg)by intragastric administration. Observed islet cell morphology with histopathological techniques and tested the apoptosis of islet cells by MTT and Annexin V/PI method. Conclusion: Dendrobium mixture could reduce the levels of blood glucose, triglyceride and glucosylated serum protein effectively and significantly improve the modeling structure and function of rat pancreatic tissue. The apoptotic islet cells was significantly reduced (P <0.01 )in treatment group compared with the model group. Results: Dendrobium mixture have a hypoglycemic effect on rat models of type 2 diabetes. It can protect and restore the structure and function of pancreatic tissue.关键词
石斛合剂/2型糖尿病模型/降糖/胰岛细胞/凋亡Key words
Dendrobium mixture/Type 2 diabetes mode/Hypoglycemic/Islet cell/Apoptosis分类
医药卫生引用本文复制引用
黎同明,邓敏贞..石斛合剂对2型糖尿病模型大鼠的降糖作用及其对胰岛细胞凋亡的影响[J].中药材,2012,35(5):765-769,5.
