中药材2012，Vol.35Issue(5)：803-807,5.
丹皮酚阳离子脂质体凝胶剂的稳定性及离体皮肤渗透试验研究
Study on Stability and Cutaneous Permeation Kineticsin vitro of Positive-ionized Liposome Gel Containing Paeonol
时军 1王芳 1滕希峰 1黄嗣航1
作者信息
- 1. 广东药学院中药学院,广东广州510006
- 折叠
摘要
Abstract
Objective:To prepare positive-ionized liposome gel containing paeonol and study its stability and cutaneous permeation kinetics in vitro. Methods: Prepared the liposome gel by dispersion-ultrasonic and gridding method,and studied the stability with the impact factor experiments. Compared the permeation rate of liposome gel with conventional gel in vitro using the Franz-diffusion cell
Results: Mean diameter of the liposome was (132. 7 ± 14.1) nm with Zeta potential of ( + 33.54 ± 1. 95 ) mV and mean entrapment efficiency of (73.04±1.24)%(n=3) ,and the content of paeonol was (3. 17 ±0. 13)mg/g(n = 3). The liposome gel had a promising appearance. It was stable at the humidity and the room temperature while was sensitive at the light and the temperature from 40 ℃ to 60 ℃. The cumulative penetration amounts of the liposome gel was higher than that of the conventional gel (P <0.05). Its cutaneous penetration rate and cumulative amounts in skin were higher than those of the conventional gel (P <0.05). Conclusion:The positive-ionized liposome gel containing paeonol is stable and feasibly prepared. It can enhance the cutaneous permeation efficiency and guarantee the persistent release rate.关键词
丹皮酚/阳离子脂质体/凝胶剂/皮肤渗透动力学Key words
Paeonol/ Positive-ionized liposome/Gel/ Cutaneous permeation kinetics分类
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时军,王芳,滕希峰,黄嗣航..丹皮酚阳离子脂质体凝胶剂的稳定性及离体皮肤渗透试验研究[J].中药材,2012,35(5):803-807,5.
