中医药学报2012，Vol.40Issue(2)：10-13,4.
中药饮片对多重抗生素耐药细菌的抑菌作用
Inhibitory Effect of Chinese Herbal Medicine on Multiple Antibiotic - resistant Bacteria
摘要
Abstract
Objective: To detect whether common antipyretic and antidote Chinese Herbal Medicine have different inhibitory effects on antibiotic sensitive and resistant bacteria strains. Methods; The inhibitory effect of 28 Chinese Herbal Medicines, such as Yuxingcao ( Houttuyniae herba) , Huanglian ( Coptidis rhizome ), Huangqi ( Scutellariae radix), Dahuang (Rhei radix et rhizome) .Fangfeng (Saposhikoviae radix) ,Jinyinhua(Lonicerea japonicae flos), etc. , on antibiotic sensitive and resistant Escherichia coli and Staphylococcus haemolyticus strains were detected by agar dilution method. Results; The results showed that most of the 28 kinds of traditional Chinese medicine had no significant different inhibitory effect on antibiotic sensitive and resistant bacteria strains, only several had(4/28) ,and they were Lianqiao (Fnrsythiae fructus) , Houpo (Magnoliae officinalis cortex) , Juemingzi (Cassiae semen) , Gancao (Glycyrrhizae radix et rhizoma). Antibiotic resistant strains were usually more sensitive to the Chinese Herbal Medicine than the sensitive ones. Moreover, some Chinese Herbal Medicines had better inhibitory effects on both Escherichia coli and Staphylococcus haemolyticus strains, such as Huanglian (Coptidis rhizome) , Huangqin (Scutellariae radix), Dahuang (Rhei radix et rhizome) , Jinyinhua ( Lonicerea japonicae flos), Diyu (Sanguisorbae radix), Shanzhuyu(Comi fructus), Banlangen (Isatidis radix) , etc. ; Others had less inhibitory effects, such as Yuxingcao (Houttuyniae herba), Sangbaipi (Mori cortex) , Shandougen (Sophorae tonkinensis radix et rhizome) , Fangfeng (Saposhnikoviae radix) , Pugongying (Taraxa-ci herba) , Pipaye (Eriobotryae folium) , etc. . Conclusion: Only a small number of these 28 traditional Chinese medicines show different inhibitory effects on antibiotic sensitive and resistant bacteria strains, and the resistant strains are often more sensitive than the sensitive ones. The results suggest that the combination of traditional Chinese medicine and western medicine may have advantages in the treatment of bacterial infectious diseases.关键词
中药/抗生素/抗药性/细菌Key words
Chinese medicine/ Antibiotics/ Resistance/ Bacteria分类
医药卫生引用本文复制引用
陈美玲,王剑,周红霞,金建玲..中药饮片对多重抗生素耐药细菌的抑菌作用[J].中医药学报,2012,40(2):10-13,4.基金项目
国家自然科学基金(No.81041089). （No.81041089）
