中医药学报2012，Vol.40Issue(2)：78-81,4.
基于分子对接的车前草抗炎机制研究
Molecular - dock Based Study on Anti - inflammatory Mechanism of Plantago Asiatica L
王芳芳 1潘竞先 1欧阳飚1
作者信息
- 1. 浙江中医药大学附属第三医院,浙江杭州310005
- 折叠
摘要
Abstract
Objective: Studies on material basis of Plantago asiatica L's anti - inflammatory effects and optimization its chemical constituents. Methods: Take the Molecular - dock as research method, and several cyclooxygenase - complex with clear crystal structure were used as targets, research on 34 compounds of Plantago asiatica L was carried out. Results : Several compounds showed interaction to the targets, the aucubin, geniposidic - acid, catalpol among them had stronger interaction to the targets, and they were consistent with experimental results reported in literature, which suggested to be the most important anti - inflammatory materials. Conclusion: Application molecular - dock combining with multi - targets research technology in the search of Plantago asiatica L's anti - inflammatory compounds is feasible, and it can also provide a new reference for the study of multi - targets of Chinese herbal compounds.关键词
车前草/分子对接/抗炎/环氧化酶Key words
Plantago asiatica L/ Molecular -dock/ Anti - inflammatory/ Cyclooxygenase分类
医药卫生引用本文复制引用
王芳芳,潘竞先,欧阳飚..基于分子对接的车前草抗炎机制研究[J].中医药学报,2012,40(2):78-81,4.
