中医药学报2012，Vol.40Issue(3)：140-143,4.
左归丸与六味地黄丸对衰老大鼠抗氧化能力及海马区超微结构影响的比较研究
Comparative Study on the Effect of Zuogui Pill with Liuweidihuang Pill on the Antioxygenation Ability and Ultrastructure in Aging Rats Hippocampus
摘要
Abstract
Objective: To analyze and compare the anti -aging function' s mechanisms of the two invigorating yin formulas, Zuogui Pill and Liuweidihuang Pill, with different compatibilities of invigorating and reducing method and Sanbu group which is the main part of the two formulas. Methods; The effect of Zuogui Pill, Liuweidihuang Pill and Sanbu group which is the main part of the two formulas on the antioxygenation ability and ultrastructure in hippocampus of suba-cute aging rats induced by D - galactose was observed. Result: SOD and GSH - PX were cut down and MDA, lipofuscin and harming change of ultrastructure in hippocampus were stepped up in subacute aging rats resulted by D - gal. After the intervention of Zuogui Pill, Liuweidihuang Pill and Sanbu group, SOD and GSH - PX were raised in different degrees, MDA was degraded and the deposite of lipofuscin and damage of ultrastructure in hippocampus were reduced. Conclusion: It demonstrates that the anti -aging function of Zuogui Pill, Liuweidihuang Pill and Sanbu group might be related to degrading antioxygenation ability, cutting down the deposite of lipofuscin and brain damage and compatibility has an important effect on the stability of complex prescription of Chinese medicine indirectly.关键词
抗衰老/配伍/左归丸/六味地黄丸Key words
Anti -aging/Compatibility/Zuogui Pill/Liuweidihuang Pill分类
医药卫生引用本文复制引用
孙琳林,王书惠,卢林,刘伦翠,任岩海..左归丸与六味地黄丸对衰老大鼠抗氧化能力及海马区超微结构影响的比较研究[J].中医药学报,2012,40(3):140-143,4.基金项目
黑龙江省中医药管理局支撑项目(编号:ZHY10-W70) （编号:ZHY10-W70）
黑龙江省卫生厅科技计划支撑项目(编号:2010-281) （编号:2010-281）
