中医药学报2012，Vol.40Issue(4)：29-31,3.
黄连温胆汤对代谢综合征大鼠炎性因子及血管粘附因子的影响
The Effect of Huanglian Wendan Decoction on Inflammatory Factors and VCAM - 1 of Metabolic Syndrome Rats
摘要
Abstract
Objective:To study the effects of Huanglian Wendan decoction on inflammatory factors and VCAM - 1 of rats with metabolic syndrome induced by dietary, and analyse the mechanism. Method: Male SD rats were fed by high ener-getic diet for 20 weeks to copy the model of metabolic syndrome. 37 model rats with metabolic syndrome were randomly divided into 4 groups: model group, herb high - dose group, herb low - dose group and control group, and each group was lavaged with drugs for 4 weeks to detect H - E staining of aorta, inflammatory factors and VCAM - 1 . Result: Com-pared with the normal group, the level of IL - 6 and ADPN in model group had a statistical significance (P <0. 05). Contrast to model group, the serum level of IL - 6 and ADPN in herb high - dose group, low - dose group and control group had a statistical significance (P <0. 05). The expression of VCAM - 1 of rats in herb high - dose group,low -dose group and control group decreased obviously which had a statistical significance (P<0.05). Conclusion: Huangli-an Wendan decoction can regulate the serum level of IL - 6 and ADPN and repress the over - expression of VCAM -1.关键词
代谢综合征/黄连温胆汤/炎性因子/血管粘附分子Key words
Metabolic syndrome/ Huanglian Wendan decoction/ Inflamatory factors/ VCAM -1分类
医药卫生引用本文复制引用
刘莉,邓晓威..黄连温胆汤对代谢综合征大鼠炎性因子及血管粘附因子的影响[J].中医药学报,2012,40(4):29-31,3.基金项目
黑龙江省自然科学资金资助项目(D2007-85) （D2007-85）
