中医药学报2012，Vol.40Issue(4)：67-70,4.
锦鸡儿属和杜鹃属植物抗乙酰胆碱酯酶活性研究
Acetylcholinesterase Inhibitory Activity of the Plants of Caragana and Rhododendron
摘要
Abstract
Objective: To screen acetylcholinesterase inhibitory activity of the plants of Caragana and Rhododendron which were collected from gansu. Methods: The Plants of Caragana were extracted by ethanol and treated with base and hydro-chloric acid, and then extracted by ethyl acetate to obtain the total polyphenol fractions. The Plants of Rhododendron were extracted by ethanol, after a initial separation of silica gel column chromatography, the crude fractions were ob-tained. The AChE inhibitory activity was tested by TLC bioautographic method and modified Ellmans colorimetric method in 96 -well microplates. Results; The results indicated that Caragana korshinskii, Rhododendron capitatum, Rhododen-dron thymifolium, Rhododendron anthopogonoides were demonstrated to have significant activity , and their inhibition ra-tio was more than 50% under the concentration of 100 μg·mL-1. Conclusion;Caragana korshinskii, Rhododendron cap-itatum , Rhododendron thymifolium, Rhododendron anthopogonoides, as sources of AchE inhibitor, are worthy of futher study.关键词
锦鸡儿/杜鹃/阿尔茨海默病/乙酰胆碱酯酶Key words
Caragana/ Rhododendron/ Alzheimer' s disease/ Acetylcholinesterase分类
医药卫生引用本文复制引用
杨中铎,任晋,薛鹏辉..锦鸡儿属和杜鹃属植物抗乙酰胆碱酯酶活性研究[J].中医药学报,2012,40(4):67-70,4.基金项目
国家自然科学基金(20802031) （20802031）
兰州理工大学优秀青年教师培养计划资助项目(Q200904) （Q200904）
