中医药信息2012，Vol.29Issue(4)：67-70,4.
黄连温胆汤对代谢综合征大鼠核转录因子及肿瘤坏死因子的影响
The Effect of Huanglianwendan Decoction on NF-κB and TNF-α of Metabolic Syndrome Rats
摘要
Abstract
To explore the effective and mechanism of the treatment of HuangLianWenDan decoction for MS by detecting the lever of NF - kB and TNF - a in serum of MS rats. Methods:The 8 - week - old male SD rats were fed with high salt, high lipid and high glucose diet to build model of MS and the successful model rats were randomly divided into 4 groups; the model group, metformin group, huanglianwendan decoction high dose group,and low dose group. After gavaging the corresponding drug to rats 4 weeks, detect the weight, blood pressure, blood glucose, serum insulin, bio - od lipids, TNF -a and calculate the lees index, HOMA -IR, and measure the expression of NF - kB. Results; Compared with normal group, the weight,fast blood glucose, blood lipids of model group rats were significantly different (P<0.05). Contrasting to model group, the weight, blood lipid, lee's index, HOMA - IR, TNF - a of MS rats in high dose group had significantly difference (P<0.05) group. And the expression of NF - kB in three groups had significantly difference (P<0.05). Conclusions: HuanglianWendan Decoction has treatment on each aspart of MS rats. It can reduce the serum TNF - a concentration and improve aortic NF - kB expression. The mechisim of the process may be related with NF - kB molecular pathways.关键词
代谢综合征/黄连温胆汤/肿瘤坏死因子/核转录因子Key words
Metabolic syndrome/ Huanglianwendan decoction/ TNF-α/ NF-kB分类
医药卫生引用本文复制引用
刘莉,邓晓威,金娟..黄连温胆汤对代谢综合征大鼠核转录因子及肿瘤坏死因子的影响[J].中医药信息,2012,29(4):67-70,4.基金项目
黑龙江省自然科学资金资助项目(D2007-85) （D2007-85）
