中医药信息2012，Vol.29Issue(4)：121-124,4.
星点设计-响应面法优选肺炎口服液的提取工艺
Optimal Extraction of Oral Liquid for Pneumonia by Central Composite Design and Response Surface Methodology
梁喆 1张丽 1吕艳莉 1陈惠铮2
作者信息
- 1. 哈尔滨市儿童医院,黑龙江哈尔滨150010
- 2. 黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040
- 折叠
摘要
Abstract
To optimize the extraction technology of oral liquid for pneumonia.Methods; The inde-pendent variables were alcohol sediment concentration, liquid - material ratio and extraction time. The dependent variable was extraction rate of total extract from oral liquid for pneumonia. Linear or nonlinear mathematic models were used to estimate the relationship between independent and dependent variables. Central composite design and response surface methodology were used to optimize the process of extraction. The prediction was carried out through comparing the observed and predicted values. Results; The optimum technological parameters were as follows; alcohol sediment concentration 75. 76% , liquid - material ratio of 1:9. 19 and extraction time 2. 08 hours. The highest extraction rate of essential oil was 10. 46mg/ml which was agreed with model predictions. Conclusion;The extraction technology is simple, reliable and highly predictive.关键词
肺炎口服液/提取工艺/星点设计/响应面法Key words
Oral liquid for pneumonia/ Extraction technology/ Central composite design/ Response surface methodology分类
医药卫生引用本文复制引用
梁喆,张丽,吕艳莉,陈惠铮..星点设计-响应面法优选肺炎口服液的提取工艺[J].中医药信息,2012,29(4):121-124,4.
