中医药信息2012，Vol.29Issue(4)：127-128,2.
针刺对实验性脑出血大鼠脑组织bFGF表达的影响
Effect of Acupuncture on the Expression of bFGF in the Brain Tissue around Hematoma of Rats with Intercerebral Hemorrhage
摘要
Abstract
To study the dynamic expression of bFGF after acute intercerebral hemorrhage ( ICH ) in rats and the influence of acupuncture on it. Methods; The 96 healthy Wistar male rats were selected. The rats were divided into three groups randomly:model group, pinprick group and western medicine group,30 rats in each group. Each group was divided into five time phase points of 6 hours,24 hours,48 hours,72 hours and 168 hours,6 rats in each group. The experiment ICH model was made by injection antologous blood using ster-eotactic method.Another six rats were assigned as the matched blank group.We observed the expression of bFGF of the intercerebral hemorrage rats with the methods of western - blot. Results;The expressions of bFGF in pinprick group significantly up - regulated than those in the model group(P <0.01). Conclusion; Adjusting upwards expression of bFGF in brain may be one important mechanism.By intervention from early stage, acupuncture may adjust upwards expression of bFGF in the brain tissue around hematoma of rats with ICH so as to reduce the neuronal injury and promote nerve repair and regeneration.关键词
脑出血/针刺/碱性成纤维细胞生长因子Key words
Acupuncture/ Intercerebral hemorrage/ bFGF分类
医药卫生引用本文复制引用
李丹,邹伟,王珑,孙晓伟,滕伟..针刺对实验性脑出血大鼠脑组织bFGF表达的影响[J].中医药信息,2012,29(4):127-128,2.基金项目
国家自然科学基金项目(30772840) （30772840）
