北京大学学报（医学版）2012，Vol.44Issue(4)：547-550,4.DOI:10.3969/j.issn.1671-167X.2012.04.012
非嵌合型克氏综合征患者显微取精成功3例报告
Successful microdissection testicular sperm extraction in patients with nonmosaic Klinefelter syndrome: three cases report
赵连明 1马潞林 1姜辉 1洪锴 1黄锦 2唐文豪 1毛加明 1乔杰 2刘平 2廉颖2
作者信息
- 1. 北京大学第三医院泌尿外科,北京100191
- 2. 北京大学第三医院妇产科,北京100191
- 折叠
摘要
Abstract
Objective: To discuss the method for patients with nonmosaic Klinefelter syndrome ( KS ) to father children. Methods: Microdissection testicular sperm extraction (micro-TESE) was performed for three patients with nonmosaic KS in our hospital. Results: Three patients (their ranging from 23 years to 36 years) , were diagnosed with azoospermia after several semen analyses. By palpation, their testis size was estimated about 3 mL, 1 mL, and 4 mL, respectively. Follicle-stimulating hormone (FSH) was 37.2 IU/L, 42.2 IU/L, and 30.5 IU/L, respectively. Luteinizing hormone (LH) was 15.5 IU/L, 11.2IU/L, and 10.1 IU/L, respectively. Testosterone was 1. 2 nmol/L, 5. 6 nmol/L, and 8. 2 nmol/L, respectively. The volume of semen was 0. 8 mL, 0. 2 mL, and 0. 5 mL, respectively. There was no sperm and fructose was positive. The transrectal B-bilateral showed vas deferens and seminal vesicles were not abnormal. And all the patients had a uniform 47 , XXY karyotype. During the operation, normal formation sperms were found in two patients. They only underwent one-side micro-TESE. Active sperms were found after being cultured. The sperms were kept under cryopreservation. The other patient underwent two-side micro-TESE. No sperm was found during the operation. After the operation, a few deformity sperms were found during the second searching. No active sperm was found after being cultured. The sperm wasn' t kept under cryopreservation. Conclusion: Although patients with nonmosaic KS have small testis and decreased spermatogenesis, some of them can obtain sperms by micro-TESE instead of accepting artificial insemination by donors.关键词
Klinefelter综合征/睾丸/抽吸/精子/授精,人工/显微外科手术Key words
Klinefelter syndrome/ Testis/ Suction/ Spermatozoa/ Insemination, artificial/ Microsur-gery分类
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赵连明,马潞林,姜辉,洪锴,黄锦,唐文豪,毛加明,乔杰,刘平,廉颖..非嵌合型克氏综合征患者显微取精成功3例报告[J].北京大学学报（医学版）,2012,44(4):547-550,4.
