北京大学学报（医学版）2012，Vol.44Issue(5)：673-677,5.DOI:10.3969/j.issn.1671-167X.2012.05.003
背腹轴线形成的机制及其临床意义
Mechanisms of dorsoventral axis formation and its clinical implications
高红 1朱正仑1
作者信息
- 1. Department of Medicine,Brigham and Women' s Hospital,Harvard Medical School,Boston,MA 02115,USA
- 折叠
摘要
Abstract
Dorsal-ventral axis formation is one of the earliest and the most important steps of patterning formation during early embryogenesis.The molecular basis of dorsoventral axis formation reflects the fundamental issues of orchestrated cell proliferation and differentiation.Wildly speculated since the Renaissance,the effort of deciphering the mechanisms of dorsal-ventral axis formation has contributed significantly to our current understanding of disease pathogenesis.Here,we focused our discussion on the recent discovery of the convergence of dorsal and ventral signaling pathways during early embryogenesis and its implications in cancer biology and beyond.关键词
胚胎发育/骨形态发生蛋白质类/Wnt蛋白质类/背腹轴线Key words
Embryonic development/ Bone morphogenetic proteins/ Wnt proteins/ Dorso-ventral axis分类
医药卫生引用本文复制引用
高红,朱正仑..背腹轴线形成的机制及其临床意义[J].北京大学学报（医学版）,2012,44(5):673-677,5.
