北京大学学报（医学版）2012，Vol.44Issue(5)：720-724,5.DOI:10.3969/j.issn.1671-167X.2012.05.011
特纳综合征患者血清转化生长因子β的变化
Perturbation of the transforming growth factor β system in Turner syndrome
摘要
Abstract
Objective:To measure components of the circulating transforming growth factor β (TGFβ)system in patients with Turner syndrome (TS) compared to relevant controls and to ascertain correlation with endocrine and cardiovascular parameters.Methods:TGFβ1,TGFβ2 and endoglin (a vascular TGF receptor component) were measured using enzyme-linked immunoassays in the sera of 40 subjects with TS and 40 healthy volunteer women.The cardiovascular phenotype in TS subjects was extensively characterized by cardiac magnetic resonance (MR) and echo.Results:TGFβ1 levels were about 3-fold higher in TS while TGFβ2 levels were about 3.5-fold higher in controls (P ＜0.000 1 for both).Soluble endoglin levels were 25％ higher in TS (P ＜0.000 1 ).Variation in TGFβ system components was not explained by age,blood pressure,platelet count,thyroid function,body proportions or cardiovascular phenotype.Conclusion:There is profound perturbation of the TGFβ system evident in the circulation of individuals with TS.关键词
特纳综合征/转化生长因子β/心血管疾病/X染色体/主动脉Key words
Turner syndrome/ Transforming growth factor beta/ Cardiovascular diseases/X chromosome/Aorta分类
医药卫生引用本文复制引用
周键,Sruthi AREPALLI,Clara M. CHENG,Vladimir K. BAKALOV,Carolyn A. BONDY..特纳综合征患者血清转化生长因子β的变化[J].北京大学学报（医学版）,2012,44(5):720-724,5.基金项目
Supported by National Institute of Child Health and Human Development （）
