北京大学学报（医学版）2012，Vol.44Issue(5)：732-736,5.DOI:10.3969/j.issn.1671-167X.2012.05.013
不同重复经颅磁刺激模式对精神分裂症认知功能和精神症状的影响
Effects of repetitive transcranial magnetic stimulation with different paradigms on the cognitive function and psychotic symptoms of schizophrenia patients
摘要
Abstract
Objective: To evaluate the effect of different paradigms of repetitive transcranial magnetic stimulation ( rTMS) on the treatment of schizophrenia through assessing cognitive function and psychotic symptoms. Methods: Eighty patients diagnosed with schizophrenia were randomly assigned to four groups, which were sham intervention group, theta burst stimulation (TBS) group, 10 Hz group and 20 Hz group. All the subjects were exposed to 5 daily treatments at 80% of motor threshold over the left dor-solateral prefrontal cortex with a total stimuli of 1 200 per day, while being maintained on their former an-tipsychotic treatment. Visual spatial working memory test and verbal fluency test were applied to evaluate the cognitive function, while Positive and Negative Symptom Scale ( PANSS) was used to assess the psychotic symptoms. Results: 20 Hz of rTMS could improve the visual spatial working memory of schizophrenia patients(t= -2. 469 ,P =0. 024). Only patients in TBS group showed significant improvement of verbal fluency test after rTMS treatment( t = -4. 538 ,P =0. 000) . The negative symptoms were alleviated significantly both in TBS and 10 Hz groups ( TBS: t = 5. 373 , P = 0. 000; 10 Hz: t = 2. 272 , P = 0. 036). General psychopathology symptoms were improved significantly both in 10 Hz and 20 Hz groups (10 Hz:t=2.725,P=0.014;20 Hz:t =3. 632, P =0. 002). Conclusion: The effects of rTMS on the cognitive function and psychotic symptoms of schizophrenia vary according to the changes in stimulus parameters , suggesting that rTMS could provide a new way for the individual therapy of schizophrenia.关键词
经颅磁刺激/精神分裂症/认知Key words
Transcranial magnetic stimulation/ Schizophrenia/ Cognition分类
医药卫生引用本文复制引用
郑丽娜,郭茜,李惠,李春波,王继军..不同重复经颅磁刺激模式对精神分裂症认知功能和精神症状的影响[J].北京大学学报（医学版）,2012,44(5):732-736,5.基金项目
上海市科学技术委员会基金(11410708800,11411966400)和国家自然科学基金(81171267)资助 （11410708800,11411966400）
