北京中医药大学学报2012，Vol.35Issue(6)：394-398,5.
丹参多组分渗透泵片的制备及体外释放度的考察
Preparation of multi-components osmotic pump tablets of Danshen (Radix Salviae Miltiorrhizae ) and release in vitro
摘要
Abstract
Objective To study the formula and preparation technique of multi-components osmotic pump tablets of Danshen (Radix Salviae Miltiorrhizae) , and observe the various factors influencing on the accumulative release of the tablets in order to make all components of Danshen to release simultaneously. Methods Taking the accumulative release of active principles of Danshen as indexes, the influences of various factors on the release were observed by using respectively single-factor test and orthogonal design test. Results The dosages of penetrating agent and porogen and coating weight gain rate had larger influences on the release. There were two index components with good similarity in release in vitro. The accumulative release of 12 hours was about 90% and showed a zero-order release. The final formula was obtained through orthogonal design test. Conclusion The extracts of Danshen can be prepared as osmotic pump tablets with constant speed and completed controlled release.关键词
丹参提取物/渗透泵片/体外释放/正交设计Key words
extracts of Danshen (Radix Salviae Miltiorrhizae) / osmotic pump tablets/ release in vitro/ orthogonal design分类
医药卫生引用本文复制引用
郑金凤,杜佩佩,闫红波,吴清..丹参多组分渗透泵片的制备及体外释放度的考察[J].北京中医药大学学报,2012,35(6):394-398,5.基金项目
国家科技重大专项资助项目(No.2009ZX09502-008),国家高新技术研究发展计划(863计划)资助项目(No.2009AA043201),中药制药过程新技术国家重点实验室开放基金资助项目(No.SKL201020304),北京中医药大学资助项目(No.2011JYBZZ-XS039) （No.2009ZX09502-008）
